(+)-tert-butyl (2R,3R)-2-(3-cyanobenzyl)-3-aminobutanoate

Base Information

Chemical Name:(+)-tert-butyl (2R,3R)-2-(3-cyanobenzyl)-3-aminobutanoate
CAS No.:899216-40-1
Molecular Formula:C₁₆H₂₂N₂O₂
Molecular Weight:274.363
Hs Code.:

Synonyms:(+)-tert-butyl (2R,3R)-2-(3-cyanobenzyl)-3-aminobutanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-tert-butyl (2R,3R)-2-(3-cyanobenzyl)-3-aminobutanoate

Chemical Property:

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Technology Process of (+)-tert-butyl (2R,3R)-2-(3-cyanobenzyl)-3-aminobutanoate

There total 5 articles about (+)-tert-butyl (2R,3R)-2-(3-cyanobenzyl)-3-aminobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2R,3R)-2-(3-Cyano-benzyl)-3-{[1-phenyl-meth-(E)-ylidene]-amino}-butyric acid tert-butyl ester

: 899216-40-1
(+)-tert-butyl (2R,3R)-2-(3-cyanobenzyl)-3-aminobutanoate

Guidance literature:: With hydroxylamine hydrochloride; In tetrahydrofuran; water; at 20 ℃; for 0.25h;
DOI:10.1021/jo060588d

Reference yield:

: 899216-33-2
(-)-tert-butyl (2R,3R)-2-(3-cyanobenzyl)-3-(benzylamino)butanoate

: 899216-40-1
(+)-tert-butyl (2R,3R)-2-(3-cyanobenzyl)-3-aminobutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: DBU; N-tert-butylbenzensulfimidoyl chloride / CH₂Cl₂ / 1.5 h / -78 °C

2: 42 mg / hydroxylamine hydrochloride / tetrahydrofuran; H₂O / 0.25 h / 20 °C

With N-tert-butylbenzensulfimidoyl chloride; hydroxylamine hydrochloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jo060588d

Reference yield:

: 79218-15-8
tert-butyl (E)-crotonate

: 899216-40-1
(+)-tert-butyl (2R,3R)-2-(3-cyanobenzyl)-3-aminobutanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: (+)-1,2-dimethoxy-1,2-diphenylethane / toluene / 0.5 h / -78 °C

1.2: 84 percent / HMPA / toluene; tetrahydrofuran / 1 h / -78 °C

2.1: DBU; N-tert-butylbenzensulfimidoyl chloride / CH₂Cl₂ / 1.5 h / -78 °C

3.1: 42 mg / hydroxylamine hydrochloride / tetrahydrofuran; H₂O / 0.25 h / 20 °C

With (+)-1,2-dimethoxy-1,2-diphenylethane; N-tert-butylbenzensulfimidoyl chloride; hydroxylamine hydrochloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1021/jo060588d