1-[5-chloro-2-(trideuteriomethoxy)phenyl]-3-[1-[dideuterio(1H-pyrrolo[2,3-b]pyridin-4-yl)methyl]indolin-4-yl]urea hydrochloride

Base Information

Chemical Name:1-[5-chloro-2-(trideuteriomethoxy)phenyl]-3-[1-[dideuterio(1H-pyrrolo[2,3-b]pyridin-4-yl)methyl]indolin-4-yl]urea hydrochloride
CAS No.:1362852-66-1
Molecular Formula:C₂₄H₂₂ClN₅O₂*ClH
Molecular Weight:489.345
Hs Code.:

Synonyms:1-[5-chloro-2-(trideuteriomethoxy)phenyl]-3-[1-[dideuterio(1H-pyrrolo[2,3-b]pyridin-4-yl)methyl]indolin-4-yl]urea hydrochloride

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Chemical Property of 1-[5-chloro-2-(trideuteriomethoxy)phenyl]-3-[1-[dideuterio(1H-pyrrolo[2,3-b]pyridin-4-yl)methyl]indolin-4-yl]urea hydrochloride

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Technology Process of 1-[5-chloro-2-(trideuteriomethoxy)phenyl]-3-[1-[dideuterio(1H-pyrrolo[2,3-b]pyridin-4-yl)methyl]indolin-4-yl]urea hydrochloride

There total 4 articles about 1-[5-chloro-2-(trideuteriomethoxy)phenyl]-3-[1-[dideuterio(1H-pyrrolo[2,3-b]pyridin-4-yl)methyl]indolin-4-yl]urea hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1362855-53-5
C₂₉H₂₅⁽²⁾H₅ClN₅O₄

: 1362852-66-1
1-[5-chloro-2-(trideuteriomethoxy)phenyl]-3-[1-[dideuterio(1H-pyrrolo[2,3-b]pyridin-4-yl)methyl]indolin-4-yl]urea hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; at 20 ℃; for 48h;

Reference yield:

: 1362855-35-3
C₈H₆⁽²⁾H₂N₂O

: 1362852-66-1
1-[5-chloro-2-(trideuteriomethoxy)phenyl]-3-[1-[dideuterio(1H-pyrrolo[2,3-b]pyridin-4-yl)methyl]indolin-4-yl]urea hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / dichloromethane / 1 h / 20 °C

2.1: triethylamine / dmap / 0.5 h / 20 °C

3.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 48 h / 20 °C

4.1: hydrogenchloride / methanol / 48 h / 20 °C

With hydrogenchloride; thionyl chloride; sodium hydrogencarbonate; triethylamine; dmap; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1362855-36-4
C₈H₅⁽²⁾H₂ClN₂

: 1362852-66-1
1-[5-chloro-2-(trideuteriomethoxy)phenyl]-3-[1-[dideuterio(1H-pyrrolo[2,3-b]pyridin-4-yl)methyl]indolin-4-yl]urea hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dmap / 0.5 h / 20 °C

2.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 48 h / 20 °C

3.1: hydrogenchloride / methanol / 48 h / 20 °C

With hydrogenchloride; sodium hydrogencarbonate; triethylamine; dmap; In methanol; N,N-dimethyl-formamide;