(2'S)-L-N⁴-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxy-2'-trifluoromethyl-4'-thiocytidine

Base Information

• Chemical Name: (2'S)-L-N⁴-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxy-2'-trifluoromethyl-4'-thiocytidine
• CAS No.: 402757-25-9
• Molecular Formula: C₂₃H₃₀F₃N₃O₃SSi
• Molecular Weight: 513.656
• Mol file: 402757-25-9.mol

Synonyms:(2'S)-L-N⁴-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxy-2'-trifluoromethyl-4'-thiocytidine

Chemical Property of (2'S)-L-N⁴-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxy-2'-trifluoromethyl-4'-thiocytidine

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (2'S)-L-N⁴-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxy-2'-trifluoromethyl-4'-thiocytidine

There total 1 articles about (2'S)-L-N⁴-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxy-2'-trifluoromethyl-4'-thiocytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-N-benzoylcytosine (26661-13-2) + (3S,5R)-5-(tert-butyldimethyl-silanoxymethyl)-3-trifluoromethyl-tetrahydrothiophen-2-yl acetate → (2'S)-L-N4-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxy-2'-trifluoromethyl-4'-thiocytidine (402757-25-9) + (2'S)-L-N4-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxy-2'-trifluoromethyl-4'-thiocytidine (402757-23-7)

Guidance literature:

4-N-benzoylcytosine; (3S,5R)-5-(tert-butyldimethyl-silanoxymethyl)-3-trifluoromethyl-tetrahydrothiophen-2-yl acetate; With N,O-bis-(trimethylsilyl)-acetamide; In acetonitrile; for 0.5h; Heating;

With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 0 - 20 ℃; for 24h; Further stages.;

DOI:10.1021/jo0159690

Reference yield:

(2'S)-L-N4-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxy-2'-trifluoromethyl-4'-thiocytidine (402757-25-9) → N-[1-((2S,3S,5R)-5-Hydroxymethyl-3-trifluoromethyl-tetrahydro-thiophen-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-benzamide

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1021/jo0159690

upstream raw materials:

4-N-benzoylcytosine