(1S,3R)-3-Formyl-2,2-dimethyl-cyclopropanecarboxylic acid benzyl-(4-methoxy-benzyl)-amide

Base Information

Chemical Name:(1S,3R)-3-Formyl-2,2-dimethyl-cyclopropanecarboxylic acid benzyl-(4-methoxy-benzyl)-amide
CAS No.:208344-74-5
Molecular Formula:C₂₂H₂₅NO₃
Molecular Weight:351.445
Hs Code.:

Synonyms:(1S,3R)-3-Formyl-2,2-dimethyl-cyclopropanecarboxylic acid benzyl-(4-methoxy-benzyl)-amide

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Chemical Property of (1S,3R)-3-Formyl-2,2-dimethyl-cyclopropanecarboxylic acid benzyl-(4-methoxy-benzyl)-amide

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Technology Process of (1S,3R)-3-Formyl-2,2-dimethyl-cyclopropanecarboxylic acid benzyl-(4-methoxy-benzyl)-amide

There total 3 articles about (1S,3R)-3-Formyl-2,2-dimethyl-cyclopropanecarboxylic acid benzyl-(4-methoxy-benzyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 208344-72-3
(1S,3R)-3-Hydroxymethyl-2,2-dimethyl-cyclopropanecarboxylic acid benzyl-(4-methoxy-benzyl)-amide

: 208344-74-5
(1S,3R)-3-Formyl-2,2-dimethyl-cyclopropanecarboxylic acid benzyl-(4-methoxy-benzyl)-amide

Guidance literature:: With pyridinium chlorochromate; In dichloromethane; for 12h; Ambient temperature;
DOI:10.1021/jm980033d

Reference yield:

: 72800-60-3
3-methyl-2-buten-1-yl diazoacetate

: 208344-74-5
(1S,3R)-3-Formyl-2,2-dimethyl-cyclopropanecarboxylic acid benzyl-(4-methoxy-benzyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: Rh₂<5(S)-MEPY>4 / CH₂Cl₂ / Heating

2: 1.) Me₃Al / 1.) hexane, 1,2-dichloroethane, RT, 30 min, 2.) hexane, 1,2-dichloroethane, reflux, 24 h

3: 93 percent / pyridinium chlorochromate / CH₂Cl₂ / 12 h / Ambient temperature

With trimethylaluminum; pyridinium chlorochromate; Doyle dirhodium catalyst; In dichloromethane;
DOI:10.1021/jm980033d

Reference yield:

: 82442-72-6
(1S,5R)-(-)-6,6-dimethyl-3-oxabicyclo[3.1.0]hexan-2-one

: 208344-74-5
(1S,3R)-3-Formyl-2,2-dimethyl-cyclopropanecarboxylic acid benzyl-(4-methoxy-benzyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Me₃Al / 1.) hexane, 1,2-dichloroethane, RT, 30 min, 2.) hexane, 1,2-dichloroethane, reflux, 24 h

2: 93 percent / pyridinium chlorochromate / CH₂Cl₂ / 12 h / Ambient temperature

With trimethylaluminum; pyridinium chlorochromate; In dichloromethane;
DOI:10.1021/jm980033d