3-chloro-N-{2-methyl-3-[3-(methyloxy)phenyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-4-yl}benzenesulfonamide

Base Information

Chemical Name:3-chloro-N-{2-methyl-3-[3-(methyloxy)phenyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-4-yl}benzenesulfonamide
CAS No.:1312593-96-6
Molecular Formula:C₂₁H₁₇ClN₂O₄S₂
Molecular Weight:460.962
Hs Code.:

Synonyms:3-chloro-N-{2-methyl-3-[3-(methyloxy)phenyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-4-yl}benzenesulfonamide

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Chemical Property of 3-chloro-N-{2-methyl-3-[3-(methyloxy)phenyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-4-yl}benzenesulfonamide

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Technology Process of 3-chloro-N-{2-methyl-3-[3-(methyloxy)phenyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-4-yl}benzenesulfonamide

There total 9 articles about 3-chloro-N-{2-methyl-3-[3-(methyloxy)phenyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-4-yl}benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312593-95-5
3-chloro-N-{2-methyl-6-(methyloxy)-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridin-4-yl}benzenesulfonamide

: 1312593-96-6
3-chloro-N-{2-methyl-3-[3-(methyloxy)phenyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-4-yl}benzenesulfonamide

Guidance literature:: With hydrogenchloride; water; at 100 ℃; Inert atmosphere;

Reference yield:

: 591-31-1
3-methoxy-benzaldehyde

: 1312593-96-6
3-chloro-N-{2-methyl-3-[3-(methyloxy)phenyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-4-yl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: diethyl ether; tetrahydrofuran / 3 h / Cooling with ice

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C

2.2: 1 h / -78 °C

3.1: 1,1,1,3,3,3-hexamethyl-disilazane; acetic acid / 12 h / 70 °C / Inert atmosphere

4.1: sulfur; sodium hydrogencarbonate; water / tetrahydrofuran / 16 h / 35 °C

5.1: tin(IV) chloride / toluene / 2 h / Reflux; Inert atmosphere

6.1: sodium hydroxide; water / ethanol / 2 h / Reflux

6.2: pH 7

6.3: 2 h / 200 °C / Inert atmosphere

7.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere

8.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

8.2: 20 °C / Inert atmosphere

9.1: hydrogenchloride; water / 100 °C / Inert atmosphere

With hydrogenchloride; oxalyl dichloride; water; tin(IV) chloride; sodium hydrogencarbonate; potassium carbonate; sulfur; acetic acid; dimethyl sulfoxide; 1,1,1,3,3,3-hexamethyl-disilazane; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 37951-49-8
1-(3-methoxyphenyl)propan-1-one

: 1312593-96-6
3-chloro-N-{2-methyl-3-[3-(methyloxy)phenyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-4-yl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1,1,1,3,3,3-hexamethyl-disilazane; acetic acid / 12 h / 70 °C / Inert atmosphere

2.1: sulfur; sodium hydrogencarbonate; water / tetrahydrofuran / 16 h / 35 °C

3.1: tin(IV) chloride / toluene / 2 h / Reflux; Inert atmosphere

4.1: sodium hydroxide; water / ethanol / 2 h / Reflux

4.2: pH 7

4.3: 2 h / 200 °C / Inert atmosphere

5.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

6.2: 20 °C / Inert atmosphere

7.1: hydrogenchloride; water / 100 °C / Inert atmosphere

With hydrogenchloride; water; tin(IV) chloride; sodium hydrogencarbonate; potassium carbonate; sulfur; acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;