N^α-(2-naphthylsulfonyl)-3-cyano-L-phenylalanyl-4-(2-hydroxyethyl)piperazide

Base Information

Chemical Name:N^α-(2-naphthylsulfonyl)-3-cyano-L-phenylalanyl-4-(2-hydroxyethyl)piperazide
CAS No.:161357-44-4
Molecular Formula:C₂₆H₂₈N₄O₄S
Molecular Weight:492.599
Hs Code.:

N<sup>α</sup>-(2-naphthylsulfonyl)-3-cyano-L-phenylalanyl-4-(2-hydroxyethyl)piperazide

Synonyms:N^α-(2-naphthylsulfonyl)-3-cyano-L-phenylalanyl-4-(2-hydroxyethyl)piperazide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N^α-(2-naphthylsulfonyl)-3-cyano-L-phenylalanyl-4-(2-hydroxyethyl)piperazide

Chemical Property:

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Technology Process of N^α-(2-naphthylsulfonyl)-3-cyano-L-phenylalanyl-4-(2-hydroxyethyl)piperazide

There total 4 articles about N^α-(2-naphthylsulfonyl)-3-cyano-L-phenylalanyl-4-(2-hydroxyethyl)piperazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 93-11-8
2-Naphthalenesulfonyl chloride

: 161357-44-4
N^α-(2-naphthylsulfonyl)-3-cyano-L-phenylalanyl-4-(2-hydroxyethyl)piperazide

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / N-methylmorpholine / dioxane; ethyl acetate / 16 h / Ambient temperature

2: 92 percent / 1N aq. HCl, AcOH / 2 h / Heating

3: SOCl₂ / 1 h / Heating

4: tetrahydrofuran / 1 h

With 4-methyl-morpholine; hydrogenchloride; thionyl chloride; acetic acid; In tetrahydrofuran; 1,4-dioxane; ethyl acetate;
DOI:10.1021/jm960668h

Reference yield:

: 144831-77-6
(S)-3-(3-cyanophenyl)-2-(naphthalene-2-sulfonamido)propanoic acid

: 161357-44-4
N^α-(2-naphthylsulfonyl)-3-cyano-L-phenylalanyl-4-(2-hydroxyethyl)piperazide

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / 1 h / Heating

2: tetrahydrofuran / 1 h

With thionyl chloride; In tetrahydrofuran;
DOI:10.1021/jm960668h

Reference yield:

: 194085-41-1
methyl (S)-3-(3-cyanophenyl)-2-(naphthalene-2-sulfonamido)propanoate

: 161357-44-4
N^α-(2-naphthylsulfonyl)-3-cyano-L-phenylalanyl-4-(2-hydroxyethyl)piperazide

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / 1N aq. HCl, AcOH / 2 h / Heating

2: SOCl₂ / 1 h / Heating

3: tetrahydrofuran / 1 h

With hydrogenchloride; thionyl chloride; acetic acid; In tetrahydrofuran;
DOI:10.1021/jm960668h