QS 6

Base Information

• Chemical Name: QS 6
• CAS No.: 58186-00-8
• Molecular Formula: C₁₅H₂₀O₆
• Molecular Weight: 296.32
• Mol file: 58186-00-8.mol

Synonyms:

Chemical Property of QS 6

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of QS 6

There total 5 articles about QS 6 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

6-(2'-hydroxy-3',4'-dimethoxy-6'-methylphenyl)hexanoic acid (58185-86-7) → 6-(5,6-dimethoxy-3-methyl-1,4-benzoquinon-2-yl)hexanoic acid (58186-00-8)

Guidance literature:

With sodium hydroxide; potassium nitrososulfonate; In water; for 1h; Ambient temperature;

DOI:10.1248/cpb.30.2797

Reference yield:

ethyl 6-chloro-6-oxohexanoate (1071-71-2) → 6-(5,6-dimethoxy-3-methyl-1,4-benzoquinon-2-yl)hexanoic acid (58186-00-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) AlCl₃, 2.) 12percent methanolic KOH / 1.) nitrobenzene, 0 deg C, 6 h, RT, 64 h

2: 1.) NaBH₄, 2.) H₂ / 2.) 5percent Pd/C / 1.) methanol, 2.) acetic acid, RT, 70 min. Other reagent: Zn/Hg

3: 86 percent / ON(SO₃K)2, 1percent NaOH / H₂O / 1 h / Ambient temperature

With potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; aluminium trichloride; potassium nitrososulfonate; hydrogen; palladium on activated charcoal; In water;

DOI:10.1248/cpb.30.2797

Reference yield:

5-(2-hydroxy-3,4-dimethoxy-6-methylbenzoyl)valeric acid (58185-80-1) → 6-(5,6-dimethoxy-3-methyl-1,4-benzoquinon-2-yl)hexanoic acid (58186-00-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaBH₄, 2.) H₂ / 2.) 5percent Pd/C / 1.) methanol, 2.) acetic acid, RT, 70 min. Other reagent: Zn/Hg

2: 86 percent / ON(SO₃K)2, 1percent NaOH / H₂O / 1 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; potassium nitrososulfonate; hydrogen; palladium on activated charcoal; In water;

DOI:10.1248/cpb.30.2797

upstream raw materials:

6-(2'-hydroxy-3',4'-dimethoxy-6'-methylphenyl)hexanoic acid

ethyl 6-chloro-6-oxohexanoate

3,4,5-trimethoxytoluene

5-(2-hydroxy-3,4-dimethoxy-6-methylbenzoyl)valeric acid