3-(4-bromobenzenesulfonyl)-4H-thieno[2,3-e][1,2,3]-triazolo[1,5-a]pyrimidin-5-one

Base Information

Chemical Name:3-(4-bromobenzenesulfonyl)-4H-thieno[2,3-e][1,2,3]-triazolo[1,5-a]pyrimidin-5-one
CAS No.:1174392-21-2
Molecular Formula:C₁₃H₇BrN₄O₃S₂
Molecular Weight:411.26
Hs Code.:

Synonyms:3-(4-bromobenzenesulfonyl)-4H-thieno[2,3-e][1,2,3]-triazolo[1,5-a]pyrimidin-5-one

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Chemical Property of 3-(4-bromobenzenesulfonyl)-4H-thieno[2,3-e][1,2,3]-triazolo[1,5-a]pyrimidin-5-one

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Technology Process of 3-(4-bromobenzenesulfonyl)-4H-thieno[2,3-e][1,2,3]-triazolo[1,5-a]pyrimidin-5-one

There total 5 articles about 3-(4-bromobenzenesulfonyl)-4H-thieno[2,3-e][1,2,3]-triazolo[1,5-a]pyrimidin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1383563-52-7
isobutyl 3-azidothiophene-2-carboxylate

: 126891-45-0
2-((4-bromophenyl)sulfonyl)acetonitrile

: 1174392-21-2
3-(4-bromobenzenesulfonyl)-4H-thieno[2,3-e][1,2,3]-triazolo[1,5-a]pyrimidin-5-one

Guidance literature:: 2-((4-bromophenyl)sulfonyl)acetonitrile; With sodium ethanolate; In ethanol; at 20 ℃; for 0.25h;

isobutyl 3-azidothiophene-2-carboxylate; In ethanol; at 20 ℃; for 0.5h;
DOI:10.1021/jm300491y

Reference yield: 53.0%

: 1174392-21-2
3-(4-bromobenzenesulfonyl)-4H-thieno[2,3-e][1,2,3]-triazolo[1,5-a]pyrimidin-5-one

Guidance literature:: With sodium ethanolate; In ethanol; at 20 ℃; for 0.25h;

In ethanol; at 20 ℃; for 0.5h;

Reference yield:

: 930-96-1
3-bromo-2-thiophenecarboxaldehyde

: 1174392-21-2
3-(4-bromobenzenesulfonyl)-4H-thieno[2,3-e][1,2,3]-triazolo[1,5-a]pyrimidin-5-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium azide / dimethyl sulfoxide / 48 h / 65 °C

2.1: sodium chlorite; aminosulfonic acid / water; acetone / 0.5 h / 0 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 80 °C / Inert atmosphere

4.1: sodium ethanolate / ethanol / 0.25 h / 20 °C

4.2: 0.5 h / 20 °C

With sodium chlorite; sodium azide; aminosulfonic acid; sodium ethanolate; caesium carbonate; In ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm300491y