Technology Process of (S)-2,4-Bis-benzyloxy-butyric acid (1R,2R)-1-ethyl-2-(4-methoxy-benzyloxy)-pent-4-enyl ester
There total 3 articles about (S)-2,4-Bis-benzyloxy-butyric acid (1R,2R)-1-ethyl-2-(4-methoxy-benzyloxy)-pent-4-enyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-2,4-Bis-benzyloxy-butyric acid;
With
2,4,6-trichlorobenzoyl chloride; triethylamine;
In
tetrahydrofuran;
at 20 ℃;
(3R,4R)-4-(4-Methoxy-benzyloxy)-hept-6-en-3-ol;
With
dmap;
In
tetrahydrofuran; toluene;
at 20 ℃;
for 3h;
Further stages.;
DOI:10.1016/j.tet.2004.05.045
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: KOH; AgNO3 / methanol; H2O / 0.33 h / 0 °C
2.1: 2,4,6-trichlorobenzoyl chloride; Et3N / tetrahydrofuran / 20 °C
2.2: 77 percent / DMAP / tetrahydrofuran; toluene / 3 h / 20 °C
With
potassium hydroxide; 2,4,6-trichlorobenzoyl chloride; silver nitrate; triethylamine;
In
tetrahydrofuran; methanol; water;
DOI:10.1016/j.tet.2004.05.045
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: DMSO; (COCl)2; Et3N / CH2Cl2 / -78 - 20 °C
2.1: 1.3 g / ZnBr2 / diethyl ether / 2 h / 0 °C
3.1: 2,4,6-trichlorobenzoyl chloride; Et3N / tetrahydrofuran / 20 °C
3.2: 77 percent / DMAP / tetrahydrofuran; toluene / 3 h / 20 °C
With
oxalyl dichloride; 2,4,6-trichlorobenzoyl chloride; dimethyl sulfoxide; triethylamine; zinc dibromide;
In
tetrahydrofuran; diethyl ether; dichloromethane;
1.1: Swern oxidation / 2.1: Grignard reaction;
DOI:10.1016/j.tet.2004.05.045
