methyl (R)-3-phenyl-2-[1,1-bis(trifluoromethyl)-2,2,2-trifluoroethoxy]propionate

Base Information

Chemical Name:methyl (R)-3-phenyl-2-[1,1-bis(trifluoromethyl)-2,2,2-trifluoroethoxy]propionate
CAS No.:1426155-81-8
Molecular Formula:C₁₄H₁₁F₉O₃
Molecular Weight:398.225
Hs Code.:

Synonyms:methyl (R)-3-phenyl-2-[1,1-bis(trifluoromethyl)-2,2,2-trifluoroethoxy]propionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (R)-3-phenyl-2-[1,1-bis(trifluoromethyl)-2,2,2-trifluoroethoxy]propionate

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Technology Process of methyl (R)-3-phenyl-2-[1,1-bis(trifluoromethyl)-2,2,2-trifluoroethoxy]propionate

There total 1 articles about methyl (R)-3-phenyl-2-[1,1-bis(trifluoromethyl)-2,2,2-trifluoroethoxy]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 2378-02-1
1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-ol

: 13673-95-5
(S)-methyl 2-hydroxy-3-phenylpropanoate

: 1426155-81-8
methyl (R)-3-phenyl-2-[1,1-bis(trifluoromethyl)-2,2,2-trifluoroethoxy]propionate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In diethyl ether; at 0 - 20 ℃; for 24h;
DOI:10.1016/j.tetlet.2013.01.072

Reference yield: 71.0%

: 1426155-81-8
methyl (R)-3-phenyl-2-[1,1-bis(trifluoromethyl)-2,2,2-trifluoroethoxy]propionate

: 1426155-78-3
(R)-3-phenyl-2-[1,1-bis(trifluoromethyl)-2,2,2-trifluoroethoxy]propionic acid

Guidance literature:: methyl (R)-3-phenyl-2-[1,1-bis(trifluoromethyl)-2,2,2-trifluoroethoxy]propionate; With sodium hydroxide; In methanol; dichloromethane; at 20 ℃; for 24h;

With hydrogenchloride; In water; at 0 ℃; pH=1;
DOI:10.1016/j.tetlet.2013.01.072

Reference yield:

: 1426155-81-8
methyl (R)-3-phenyl-2-[1,1-bis(trifluoromethyl)-2,2,2-trifluoroethoxy]propionate

: C₁₃H₉F₉O₃*C₈H₁₁N

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / methanol; dichloromethane / 24 h / 20 °C

2: chloroform-d1

With sodium hydroxide; In methanol; chloroform-d1; dichloromethane;
DOI:10.1021/acs.joc.5b00706