ethyl 3-(2-(cyclopropanecarboxamido)thiazolo[5,4-b]pyridin-6-yl)benzoate

Base Information

Chemical Name:ethyl 3-(2-(cyclopropanecarboxamido)thiazolo[5,4-b]pyridin-6-yl)benzoate
CAS No.:1258392-02-7
Molecular Formula:C₁₉H₁₇N₃O₃S
Molecular Weight:367.428
Hs Code.:

Synonyms:ethyl 3-(2-(cyclopropanecarboxamido)thiazolo[5,4-b]pyridin-6-yl)benzoate

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Chemical Property of ethyl 3-(2-(cyclopropanecarboxamido)thiazolo[5,4-b]pyridin-6-yl)benzoate

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Technology Process of ethyl 3-(2-(cyclopropanecarboxamido)thiazolo[5,4-b]pyridin-6-yl)benzoate

There total 4 articles about ethyl 3-(2-(cyclopropanecarboxamido)thiazolo[5,4-b]pyridin-6-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1258392-01-6
ethyl 3-(5-amino-6-chloropyridin-3-yl)benzoate

: 1147550-11-5
ammonium thiocyanate

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1258392-02-7
ethyl 3-(2-(cyclopropanecarboxamido)thiazolo[5,4-b]pyridin-6-yl)benzoate

Guidance literature:: ammonium thiocyanate; cyclopropanecarboxylic acid chloride; In acetone; at 50 ℃; Reflux;

ethyl 3-(5-amino-6-chloropyridin-3-yl)benzoate; With potassium carbonate; In 1,4-dioxane; acetone; at 120 ℃; for 8h;

Reference yield:

: 4334-87-6
[3-(ethoxycarbonyl)phenyl]boronic acid

: 1258392-02-7
ethyl 3-(2-(cyclopropanecarboxamido)thiazolo[5,4-b]pyridin-6-yl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate; tert-butyl XPhos / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 10 h / 90 °C / Inert atmosphere

2.1: tert.-butylnitrite; copper dichloride / acetonitrile / 2.17 h / 70 °C

3.1: tin(II) chloride dihdyrate / ethyl acetate / 10 h / 20 °C

3.2: 0 °C

4.1: acetone / 50 °C / Reflux

4.2: 8 h / 120 °C

With tert.-butylnitrite; tin(II) chloride dihdyrate; sodium carbonate; copper dichloride; tert-butyl XPhos; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; water; ethyl acetate; acetone; acetonitrile;

Reference yield:

: 1258391-99-9
ethyl 3-(6-amino-5-nitropyridin-3-yl)benzoate

: 1258392-02-7
ethyl 3-(2-(cyclopropanecarboxamido)thiazolo[5,4-b]pyridin-6-yl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tert.-butylnitrite; copper dichloride / acetonitrile / 2.17 h / 70 °C

2.1: tin(II) chloride dihdyrate / ethyl acetate / 10 h / 20 °C

2.2: 0 °C

3.1: acetone / 50 °C / Reflux

3.2: 8 h / 120 °C

With tert.-butylnitrite; tin(II) chloride dihdyrate; copper dichloride; In ethyl acetate; acetone; acetonitrile;