3-(2-amino-4,5-dichlorophenyl)-1-cyclopropylcarbonyl-4,5-dihydro-1H-pyrazole

Base Information

Chemical Name:3-(2-amino-4,5-dichlorophenyl)-1-cyclopropylcarbonyl-4,5-dihydro-1H-pyrazole
CAS No.:1445859-52-8
Molecular Formula:C₁₃H₁₃Cl₂N₃O
Molecular Weight:298.172
Hs Code.:

Synonyms:3-(2-amino-4,5-dichlorophenyl)-1-cyclopropylcarbonyl-4,5-dihydro-1H-pyrazole

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Chemical Property of 3-(2-amino-4,5-dichlorophenyl)-1-cyclopropylcarbonyl-4,5-dihydro-1H-pyrazole

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Technology Process of 3-(2-amino-4,5-dichlorophenyl)-1-cyclopropylcarbonyl-4,5-dihydro-1H-pyrazole

There total 6 articles about 3-(2-amino-4,5-dichlorophenyl)-1-cyclopropylcarbonyl-4,5-dihydro-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1445859-33-5
1-cyclopropylcarbonyl-3-(4,5-dichloro-2-nitrophenyl)-4,5-dihydro-1H-pyrazole

: 1445859-52-8
3-(2-amino-4,5-dichlorophenyl)-1-cyclopropylcarbonyl-4,5-dihydro-1H-pyrazole

Guidance literature:: With tin(ll) chloride; In ethanol; for 2h; Reflux;
DOI:10.1016/j.bmc.2013.05.016

Reference yield:

: 1445859-27-7
1-(4,5-dichloro-2-nitrophenyl)prop-2-en-1-ol

: 1445859-52-8
3-(2-amino-4,5-dichlorophenyl)-1-cyclopropylcarbonyl-4,5-dihydro-1H-pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1: Jones reagent / acetone / 0.17 h / 20 °C

2: hydrazine hydrate / ethanol / 3 h / Reflux

3: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

4: tin(ll) chloride / ethanol / 2 h / Reflux

With Jones reagent; hydrazine hydrate; triethylamine; tin(ll) chloride; In ethanol; dichloromethane; acetone;
DOI:10.1016/j.bmc.2013.05.016

Reference yield:

: 6287-38-3
3,4-dichlorobenzaldehyde

: 1445859-52-8
3-(2-amino-4,5-dichlorophenyl)-1-cyclopropylcarbonyl-4,5-dihydro-1H-pyrazole

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid; nitric acid

2: tetrahydrofuran / 3.5 h / -70 °C

3: Jones reagent / acetone / 0.17 h / 20 °C

4: hydrazine hydrate / ethanol / 3 h / Reflux

5: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

6: tin(ll) chloride / ethanol / 2 h / Reflux

With Jones reagent; sulfuric acid; nitric acid; hydrazine hydrate; triethylamine; tin(ll) chloride; In tetrahydrofuran; ethanol; dichloromethane; acetone;
DOI:10.1016/j.bmc.2013.05.016