(1R,2S)-2-(tert-butyldiphenylsilyloxy)methyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane

Base Information

• Chemical Name: (1R,2S)-2-(tert-butyldiphenylsilyloxy)methyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane
• CAS No.: 408348-60-7
• Molecular Formula: C₄₂H₄₂N₂OSi
• Molecular Weight: 618.894
• Mol file: 408348-60-7.mol

Synonyms:(1R,2S)-2-(tert-butyldiphenylsilyloxy)methyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane

Chemical Property of (1R,2S)-2-(tert-butyldiphenylsilyloxy)methyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S)-2-(tert-butyldiphenylsilyloxy)methyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane

There total 1 articles about (1R,2S)-2-(tert-butyldiphenylsilyloxy)methyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trityl chloride (76-83-5) + 4-[2-(tert-butyl-diphenyl-silanyloxymethyl)-cyclopropyl]-1H-imidazole → (1R,2S)-2-(tert-butyldiphenylsilyloxy)methyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane (408348-60-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/jo010852x

Reference yield:

(1R,2S)-2-(tert-butyldiphenylsilyloxy)methyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane (408348-60-7) → (1R,2S)-2-hydroxymethyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane (408348-61-8)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jo010852x

Reference yield:

(1R,2S)-2-(tert-butyldiphenylsilyloxy)methyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane (408348-60-7) → (1R,2S)-2-(benzyloxyimino)methyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane

Guidance literature:

Multi-step reaction with 3 steps

1: TBAF / tetrahydrofuran / 20 °C

2: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 °C

3: 4 Angstroem molecular sieves / tetrahydrofuran / 20 °C

With oxalyl dichloride; 4 A molecular sieve; tetrabutyl ammonium fluoride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 2: Swern oxidation;

DOI:10.1021/jo010852x

upstream raw materials:

trityl chloride

Downstream raw materials:

(1R,2S)-2-hydroxymethyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane

(1R,2S)-2-formyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane