N-(o-bromobenzyl)glutarimide

Base Information

Chemical Name:N-(o-bromobenzyl)glutarimide
CAS No.:606123-25-5
Molecular Formula:C₁₂H₁₂BrNO₂
Molecular Weight:282.137
Hs Code.:

Synonyms:N-(o-bromobenzyl)glutarimide

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Chemical Property of N-(o-bromobenzyl)glutarimide

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Technology Process of N-(o-bromobenzyl)glutarimide

There total 1 articles about N-(o-bromobenzyl)glutarimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1121-89-7
piperidine-2,6-dione

: 3433-80-5
1-Bromo-2-bromomethyl-benzene

: 606123-25-5
N-(o-bromobenzyl)glutarimide

Guidance literature:: With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 5h;
DOI:10.1021/ol034942v

Reference yield:

: 606123-25-5
N-(o-bromobenzyl)glutarimide

: (E)-6-[1-(2-bromobenzyl)-6-oxopiperidin-2-yl]hex-2-enal

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / NaBH₄; HCl / -20 - 20 °C

2: 87 percent / CaCl₂ / CH₂Cl₂ / 3 h / 20 °C

3: 87 percent / ZnCl₂*Et₂O / CH₂Cl₂; diethyl ether / 2 h / 20 °C

4: 50 percent / Grubbs' catalyst / CH₂Cl₂ / 12 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; zinc chloride diethyl ether; calcium chloride; Grubbs catalyst first generation; In diethyl ether; dichloromethane;
DOI:10.1021/ol034942v

Reference yield:

: 606123-25-5
N-(o-bromobenzyl)glutarimide

: (6-benzyl-7-oxo-6-aza-spiro[4.5]dec-1-yl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / NaBH₄; HCl / -20 - 20 °C

2: 87 percent / CaCl₂ / CH₂Cl₂ / 3 h / 20 °C

3: 87 percent / ZnCl₂*Et₂O / CH₂Cl₂; diethyl ether / 2 h / 20 °C

4: 85 percent / Grubbs' catalyst / CH₂Cl₂ / 12 h / 20 °C

5: 88 percent / Bu₃SnH; AIBN / benzene / 19 h / Heating

With hydrogenchloride; sodium tetrahydroborate; zinc chloride diethyl ether; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; calcium chloride; Grubbs catalyst first generation; In diethyl ether; dichloromethane; benzene;
DOI:10.1021/ol034942v