N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-(2R)-triphenylmethylamino-3-hydroxypropylamine

Base Information

Chemical Name:N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-(2R)-triphenylmethylamino-3-hydroxypropylamine
CAS No.:288582-43-4
Molecular Formula:C₃₉H₄₅N₃O₅
Molecular Weight:635.803
Hs Code.:

Synonyms:N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-(2R)-triphenylmethylamino-3-hydroxypropylamine

Suppliers and Price of N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-(2R)-triphenylmethylamino-3-hydroxypropylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-(2R)-triphenylmethylamino-3-hydroxypropylamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-(2R)-triphenylmethylamino-3-hydroxypropylamine

There total 3 articles about N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-(2R)-triphenylmethylamino-3-hydroxypropylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 89813-47-8
N-(tert-butoxycarbonyl)-(2S,4R)-4-hydroxyproline benzyl ester

: 288582-41-2
(2R)-triphenylmethylamino-3-aminopropanol

: 288582-43-4
N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-(2R)-triphenylmethylamino-3-hydroxypropylamine

Guidance literature:: N-(tert-butoxycarbonyl)-(2S,4R)-4-hydroxyproline benzyl ester; With trifluoromethylsulfonic anhydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -30 ℃; for 1h;

(2R)-triphenylmethylamino-3-aminopropanol; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -10 ℃; for 76h; Further stages.;
DOI:10.1021/jo000071g

Reference yield:

: 13515-76-9,116457-91-1,4465-44-5
methyl N-trityl-L-serinate

: 288582-43-4
N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-(2R)-triphenylmethylamino-3-hydroxypropylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 92 percent / NH₃ / methanol / 96 h / 80 °C

2.1: 84 percent / LiAlH₄ / diethyl ether / 60 h / Heating

3.1: diisopropylethylamine; (CF₃SO₂)2O / CH₂Cl₂ / 1 h / -30 °C

3.2: 65 percent / diisopropylethylamine / CH₂Cl₂ / 76 h / -10 °C

With lithium aluminium tetrahydride; trifluoromethylsulfonic anhydride; ammonia; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; dichloromethane; 1.1: Substitution / 2.1: Reduction / 3.1: sulfonation / 3.2: Substitution;
DOI:10.1021/jo000071g

Reference yield:

: 288582-40-1
N-triphenylmethyl-L-serinamide

: 288582-43-4
N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-(2R)-triphenylmethylamino-3-hydroxypropylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 84 percent / LiAlH₄ / diethyl ether / 60 h / Heating

2.1: diisopropylethylamine; (CF₃SO₂)2O / CH₂Cl₂ / 1 h / -30 °C

2.2: 65 percent / diisopropylethylamine / CH₂Cl₂ / 76 h / -10 °C

With lithium aluminium tetrahydride; trifluoromethylsulfonic anhydride; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; 1.1: Reduction / 2.1: sulfonation / 2.2: Substitution;
DOI:10.1021/jo000071g