Friedelanol

Base Information

• Chemical Name: Friedelanol
• CAS No.: 5085-72-3
• Molecular Formula: C₃₀H₅₂O
• Molecular Weight: 428.742
• Nikkaji Number: J12.755H
• Wikidata: Q104667641
• Metabolomics Workbench ID: 127878
• ChEMBL ID: CHEMBL229563
• Mol file: 5085-72-3.mol

Synonyms:3beta-friedelinol;epi-friedelinol;epifriedelanol;friedelanol;friedelinol;friedelinol, (3beta)-isomer

Chemical Property of Friedelanol

Chemical Property:

• Vapor Pressure: 3.71E-11mmHg at 25°C
• Melting Point: 301-304 °C
• Boiling Point: 478.3°C at 760 mmHg
• PKA: 15.18±0.70(Predicted)
• Flash Point: 199.6°C
• Density: 0.966g/cm³
• XLogP3: 10.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 428.401816278
• Heavy Atom Count: 31
• Complexity: 741

Purity/Quality:

99% ^*data from raw suppliers

Friedelanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1C(CCC2C1(CCC3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C)C)C)C)C)C)O
• Isomeric SMILES: C[C@H]1[C@@H](CC[C@@H]2[C@@]1(CC[C@H]3[C@]2(CC[C@@]4([C@@]3(CC[C@@]5([C@H]4CC(CC5)(C)C)C)C)C)C)C)O

Technology Process of Friedelanol

There total 34 articles about Friedelanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

friedelin (559-74-0) → epifriedelanol (5085-72-3,7506-18-5,16844-71-6,105370-95-4)

Guidance literature:

With sodium tetrahydroborate; In methanol; dichloromethane; at -78 - 20 ℃;

DOI:10.1021/np010217m

Reference yield: 100.0%

friedelin (559-74-0) → friedelinol (7506-18-5,16844-71-6,105370-95-4,5085-72-3)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium; In butan-1-ol; for 1.5h; Heating;

DOI:10.1021/np010217m

Reference yield: 75.0%

3β,24-oxido-D:A-friedooleanane (2735-84-4) → epifriedelanol (5085-72-3,7506-18-5,16844-71-6,105370-95-4) + D:A friedoolean-24-ol (2130-12-3)

Guidance literature:

With lithium; In ethylenediamine;

DOI:10.1016/S0040-4039(00)88490-7

upstream raw materials:

friedelin

D:A-friedo-oleanane

24-ethylcholesterol

3α-acetoxyfriedelan

Downstream raw materials:

3β-acetoxy-friedelane

friedel-3⁽⁴⁾-ene

friedelin

benzoic acid-(friedelanyl-(3α)-ester)

Refernces

Chemical constituents of Diospyros buxifolia, D. tomentosa, D. ferra, D. lotus, Rhus parviflora, Polygonum recumbens, Balanites aegyptiaca and Pyrus pashia

10.1016/S0031-9422(00)97297-2

This research aimed to identify and isolate the chemical constituents of various plant species, including Diospyros buxifolia, D. tomentosa, D. ferra, D. lotus, Balanites aegyptiaca, Rhus parviflora, Polygonum recumbens, and Pyrus pashia. The study involved the extraction and chromatographic separation of compounds from these plants, leading to the identification of various triterpenes, steroids, and other chemical constituents such as friedelin, epi-friedelinol, p-sitosterol, lupeol, betulin, betulinic acid, and maslinic acid, among others. The research concluded with the detailed characterization of these compounds, including their melting points, optical rotations, and spectroscopic data, which contribute to the understanding of the phytochemical profiles of the studied plants and may have implications for their medicinal properties.