tert-butyl N-methyl-[1-(tert-butoxycarbonyl)-3-hydroxypiperidin-4-yl]carbamate

Base Information

Chemical Name:tert-butyl N-methyl-[1-(tert-butoxycarbonyl)-3-hydroxypiperidin-4-yl]carbamate
CAS No.:914988-15-1
Molecular Formula:C₁₆H₃₀N₂O₅
Molecular Weight:330.425
Hs Code.:

Synonyms:tert-butyl N-methyl-[1-(tert-butoxycarbonyl)-3-hydroxypiperidin-4-yl]carbamate

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Chemical Property of tert-butyl N-methyl-[1-(tert-butoxycarbonyl)-3-hydroxypiperidin-4-yl]carbamate

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Technology Process of tert-butyl N-methyl-[1-(tert-butoxycarbonyl)-3-hydroxypiperidin-4-yl]carbamate

There total 1 articles about tert-butyl N-methyl-[1-(tert-butoxycarbonyl)-3-hydroxypiperidin-4-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85838-94-4
N-Boc-1,2,3,6-tetrahydropyridine

: 914988-15-1
tert-butyl N-methyl-[1-(tert-butoxycarbonyl)-3-hydroxypiperidin-4-yl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 92 percent / m-chloroperoxybenzoic acid / CH₂Cl₂ / 18 h / 20 °C

2.1: ethanol / 6 h / Heating

2.2: 27 percent / CHCl₃ / 6 h / 20 °C

With 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2007.05.093

Reference yield:

: 914988-15-1
tert-butyl N-methyl-[1-(tert-butoxycarbonyl)-3-hydroxypiperidin-4-yl]carbamate

: 914989-28-9
C₂₃H₃₅N₃O₅

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / pyridine*SO₃; Et₃N / dimethylsulfoxide / 3 h / 5 °C

2: 81 percent / NaHCO₃; HONH₂*HCl / ethanol; tetrahydrofuran / 1 h / 40 °C

3: TBAB; aq. NaOH / CH₂Cl₂ / 5 h / 20 °C

With sodium hydroxide; hydroxylamine hydrochloride; tetrabutylammomium bromide; sulfur trioxide pyridine complex; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2007.05.093

Reference yield:

: 914988-15-1
tert-butyl N-methyl-[1-(tert-butoxycarbonyl)-3-hydroxypiperidin-4-yl]carbamate

: 950609-43-5
C₁₃H₁₉N₃O

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / pyridine*SO₃; Et₃N / dimethylsulfoxide / 3 h / 5 °C

2: 81 percent / NaHCO₃; HONH₂*HCl / ethanol; tetrahydrofuran / 1 h / 40 °C

3: TBAB; aq. NaOH / CH₂Cl₂ / 5 h / 20 °C

4: MeSO₃H / tetrahydrofuran / 18 h / 20 °C

With sodium hydroxide; methanesulfonic acid; hydroxylamine hydrochloride; tetrabutylammomium bromide; sulfur trioxide pyridine complex; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2007.05.093