(S)-ethyl-6-methyl-4-(2-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Base Information

Chemical Name:(S)-ethyl-6-methyl-4-(2-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS No.:1190948-85-6
Molecular Formula:C₁₄H₁₅N₃O₄S
Molecular Weight:321.357
Hs Code.:

Synonyms:(S)-ethyl-6-methyl-4-(2-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-ethyl-6-methyl-4-(2-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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Technology Process of (S)-ethyl-6-methyl-4-(2-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

There total 2 articles about (S)-ethyl-6-methyl-4-(2-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 141-97-9
ethyl acetoacetate

: 17356-08-0
thiourea

: 552-89-6
2-nitro-benzaldehyde

: 1190948-85-6
(S)-ethyl-6-methyl-4-(2-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: thiourea; 2-nitro-benzaldehyde; With C₈₀H₄₉NO₆P₂; In ethyl acetate; at 25 ℃; for 2h;

ethyl acetoacetate; In ethyl acetate; at 50 ℃; for 12h; enantioselective reaction; Mechanism;
DOI:10.1002/ejoc.201301560

Reference yield:

: 141-97-9
ethyl acetoacetate

: 17356-08-0
thiourea

: 552-89-6
2-nitro-benzaldehyde

: 1190948-85-6
(S)-ethyl-6-methyl-4-(2-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: C₁₄H₁₅N₃O₄S

Guidance literature:: thiourea; 2-nitro-benzaldehyde; With (5R,6R)-2,5,6-trihydroxy-4,4,7,7-tetraphenyl-1,3,2-dioxaphosphepane 2-oxide; In acetone; at 20 ℃; for 2h;

ethyl acetoacetate; In acetone; at 20 ℃; for 72h; Overall yield = 21 %; Optical yield = 16.6 %ee; enantioselective reaction;
DOI:10.1016/j.tetasy.2016.11.014