(4R,5S)-1-(3,4-diaminophenyl)-3-(4-methoxybenzyl)-5-(4-methoxyphenyl)-4-methylimidazolidin-2-one

Base Information

Chemical Name:(4R,5S)-1-(3,4-diaminophenyl)-3-(4-methoxybenzyl)-5-(4-methoxyphenyl)-4-methylimidazolidin-2-one
CAS No.:1276021-59-0
Molecular Formula:C₂₅H₂₈N₄O₃
Molecular Weight:432.522
Hs Code.:

Synonyms:(4R,5S)-1-(3,4-diaminophenyl)-3-(4-methoxybenzyl)-5-(4-methoxyphenyl)-4-methylimidazolidin-2-one

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Chemical Property of (4R,5S)-1-(3,4-diaminophenyl)-3-(4-methoxybenzyl)-5-(4-methoxyphenyl)-4-methylimidazolidin-2-one

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Technology Process of (4R,5S)-1-(3,4-diaminophenyl)-3-(4-methoxybenzyl)-5-(4-methoxyphenyl)-4-methylimidazolidin-2-one

There total 8 articles about (4R,5S)-1-(3,4-diaminophenyl)-3-(4-methoxybenzyl)-5-(4-methoxyphenyl)-4-methylimidazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.3%

: 1276021-58-9
(4S,5R)-1-(4-methoxybenzyl)-4-(4-methoxyphenyl)-5-methylimidazolidin-2-one

: 21304-38-1
4-iodobenzene-1,2-diamine

: 1276021-59-0
(4R,5S)-1-(3,4-diaminophenyl)-3-(4-methoxybenzyl)-5-(4-methoxyphenyl)-4-methylimidazolidin-2-one

Guidance literature:: With rac-diaminocyclohexane; cesium fluoride; copper(l) iodide; In 1,4-dioxane; at 95 ℃; for 72h; Inert atmosphere;

Reference yield:

: 4180-23-8,25086-72-0,63589-56-0
E-1-(4'-methoxyphenyl)prop-1-ene

: 1276021-59-0
(4R,5S)-1-(3,4-diaminophenyl)-3-(4-methoxybenzyl)-5-(4-methoxyphenyl)-4-methylimidazolidin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide / water; propan-1-ol / 0.08 h / 20 °C

1.2: 0.17 h / 20 °C

1.3: 0 °C

2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

3.1: sodium azide / N,N-dimethyl-formamide / 2 h / 70 °C

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 24 h / 20 °C / 3000.3 Torr / Inert atmosphere

5.1: ethanol / 4 h / 20 °C

5.2: 14 h / 0 - 20 °C

6.1: trifluoroacetic acid / dichloromethane / 20 °C

7.1: triethylamine / dichloromethane / 1 h / Reflux

8.1: cesium fluoride; rac-diaminocyclohexane / copper(l) iodide / 1,4-dioxane / 72 h / 95 °C / Inert atmosphere

With sodium azide; hydrogen; rac-diaminocyclohexane; triethylamine; cesium fluoride; trifluoroacetic acid; sodium hydroxide; copper(l) iodide; palladium 10% on activated carbon; In 1,4-dioxane; propan-1-ol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1252676-24-6
tert-butyl (1S,2R)-2-amino-1-(4-methoxyphenyl)propylcarbamate

: 1276021-59-0
(4R,5S)-1-(3,4-diaminophenyl)-3-(4-methoxybenzyl)-5-(4-methoxyphenyl)-4-methylimidazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 4 h / 20 °C

1.2: 14 h / 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 20 °C

3.1: triethylamine / dichloromethane / 1 h / Reflux

4.1: cesium fluoride; rac-diaminocyclohexane / copper(l) iodide / 1,4-dioxane / 72 h / 95 °C / Inert atmosphere

With rac-diaminocyclohexane; triethylamine; cesium fluoride; trifluoroacetic acid; copper(l) iodide; In 1,4-dioxane; ethanol; dichloromethane;