4-((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-((1R,3S)-3-(benzyloxycarbonyl)-2,2-dimethylcyclobutylcarbamoyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-yloxy)-2,2-dimethyl-4-oxobutanoic acid

Base Information

Chemical Name:4-((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-((1R,3S)-3-(benzyloxycarbonyl)-2,2-dimethylcyclobutylcarbamoyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-yloxy)-2,2-dimethyl-4-oxobutanoic acid
CAS No.:1261253-61-5
Molecular Formula:C₅₀H₇₃NO₇
Molecular Weight:800.132
Hs Code.:

4-((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-((1R,3S)-3-(benzyloxycarbonyl)-2,2-dimethylcyclobutylcarbamoyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-yloxy)-2,2-dimethyl-4-oxobutanoic acid

Synonyms:4-((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-((1R,3S)-3-(benzyloxycarbonyl)-2,2-dimethylcyclobutylcarbamoyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-yloxy)-2,2-dimethyl-4-oxobutanoic acid

Suppliers and Price of 4-((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-((1R,3S)-3-(benzyloxycarbonyl)-2,2-dimethylcyclobutylcarbamoyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-yloxy)-2,2-dimethyl-4-oxobutanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-((1R,3S)-3-(benzyloxycarbonyl)-2,2-dimethylcyclobutylcarbamoyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-yloxy)-2,2-dimethyl-4-oxobutanoic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of 4-((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-((1R,3S)-3-(benzyloxycarbonyl)-2,2-dimethylcyclobutylcarbamoyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-yloxy)-2,2-dimethyl-4-oxobutanoic acid

There total 15 articles about 4-((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-((1R,3S)-3-(benzyloxycarbonyl)-2,2-dimethylcyclobutylcarbamoyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-yloxy)-2,2-dimethyl-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.1%

: 17347-61-4
2,2-dimethylsuccinic anhydride

: 1261254-61-8
(1S,3R)-benzyl 3-((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysene-3a-carboxamido)-2,2-dimethylcyclobutanecarboxylate

: 1261253-61-5
4-((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-((1R,3S)-3-(benzyloxycarbonyl)-2,2-dimethylcyclobutylcarbamoyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-yloxy)-2,2-dimethyl-4-oxobutanoic acid

Guidance literature:: With pyridine; dmap; for 20h; Reflux;

Reference yield:

: 80-57-9,1196-01-6
(-)-Verbenone

: 1261253-61-5
4-((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-((1R,3S)-3-(benzyloxycarbonyl)-2,2-dimethylcyclobutylcarbamoyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-yloxy)-2,2-dimethyl-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium periodate; water / ruthenium(III) trichloride hydrate / tetrachloromethane; acetonitrile / 12 h / 0 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

3.1: sodium azide; methanesulfonic acid / 1,2-dimethoxyethane / 48 h / -45 - 20 °C

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1 h / 20 °C

5.1: hydrogenchloride; water / 12 h / Reflux

5.2: pH 8 - 9

5.3: 16 h / 0 - 20 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

7.1: dichloromethane / 0.5 h / 0 - 20 °C

8.1: triethylamine / dichloromethane / 16 h / -5 - 20 °C

9.1: sodium hydroxide; water / tetrahydrofuran; methanol / 6 h / 0 - 20 °C

10.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

11.1: dmap; pyridine / 20 h / Reflux

With pyridine; hydrogenchloride; dmap; sodium periodate; sodium azide; methanesulfonic acid; water; hydrogen; caesium carbonate; triethylamine; sodium hydroxide; ruthenium(III) trichloride hydrate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; tetrachloromethane; 1,2-dimethoxyethane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 3.1: Schmidt Rearrangement;

Reference yield:

: 288848-24-8
(1S,3R)-3-acetyl-2,2-dimethylcyclobutane carboxylic acid

: 1261253-61-5
4-((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-((1R,3S)-3-(benzyloxycarbonyl)-2,2-dimethylcyclobutylcarbamoyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-yloxy)-2,2-dimethyl-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

2.1: sodium azide; methanesulfonic acid / 1,2-dimethoxyethane / 48 h / -45 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1 h / 20 °C

4.1: hydrogenchloride; water / 12 h / Reflux

4.2: pH 8 - 9

4.3: 16 h / 0 - 20 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

6.1: dichloromethane / 0.5 h / 0 - 20 °C

7.1: triethylamine / dichloromethane / 16 h / -5 - 20 °C

8.1: sodium hydroxide; water / tetrahydrofuran; methanol / 6 h / 0 - 20 °C

9.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

10.1: dmap; pyridine / 20 h / Reflux

With pyridine; hydrogenchloride; dmap; sodium azide; methanesulfonic acid; water; hydrogen; caesium carbonate; triethylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 2.1: Schmidt Rearrangement;