3-methoxy-4-methyl-2-nitro-6-(1-pyrrolidinyl)benzeneacetonitrile

Base Information

Chemical Name:3-methoxy-4-methyl-2-nitro-6-(1-pyrrolidinyl)benzeneacetonitrile
CAS No.:97655-50-0
Molecular Formula:C₁₄H₁₇N₃O₃
Molecular Weight:275.307
Hs Code.:

Synonyms:3-methoxy-4-methyl-2-nitro-6-(1-pyrrolidinyl)benzeneacetonitrile

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Chemical Property of 3-methoxy-4-methyl-2-nitro-6-(1-pyrrolidinyl)benzeneacetonitrile

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Technology Process of 3-methoxy-4-methyl-2-nitro-6-(1-pyrrolidinyl)benzeneacetonitrile

There total 6 articles about 3-methoxy-4-methyl-2-nitro-6-(1-pyrrolidinyl)benzeneacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 97673-92-2
5-methoxy-4-methyl-2-(1-pyrrolidinyl)benzeneacetonitrile

: 97655-50-0
3-methoxy-4-methyl-2-nitro-6-(1-pyrrolidinyl)benzeneacetonitrile

Guidance literature:: With sulfuric acid; nitric acid; at 0 ℃; for 0.25h;
DOI:10.1021/jo00220a024

Reference yield:

: 97655-36-2
5-chloro-2-methyl-4-nitrophenol

: 97655-50-0
3-methoxy-4-methyl-2-nitro-6-(1-pyrrolidinyl)benzeneacetonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / 80percent sodium hydride / tetrahydrofuran / 3 h / Heating

2: 80percent sodium hydride / dimethylformamide / 3.5 h / 70 °C

3: 1.5 N Na₂CO₃ / 168 h / 40 °C

4: 90 percent / H₂ / 5percent Pd/C / ethyl acetate; ethanol / 24 h / 760 Torr / Ambient temperature

5: 87 percent / ethyldiisopropylamine / toluene / 4.5 h / 110 °C

6: 36 percent / concd. H₂SO₄, concd. HNO₃ / 0.25 h / 0 °C

With sulfuric acid; hydrogen; nitric acid; sodium hydride; sodium carbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00220a024

Reference yield:

: 97655-37-3
1-chloro-5-methoxy-4-methyl-2-nitrobenzene

: 97655-50-0
3-methoxy-4-methyl-2-nitro-6-(1-pyrrolidinyl)benzeneacetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 80percent sodium hydride / dimethylformamide / 3.5 h / 70 °C

2: 1.5 N Na₂CO₃ / 168 h / 40 °C

3: 90 percent / H₂ / 5percent Pd/C / ethyl acetate; ethanol / 24 h / 760 Torr / Ambient temperature

4: 87 percent / ethyldiisopropylamine / toluene / 4.5 h / 110 °C

5: 36 percent / concd. H₂SO₄, concd. HNO₃ / 0.25 h / 0 °C

With sulfuric acid; hydrogen; nitric acid; sodium hydride; sodium carbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00220a024