(2Z,8Z)-11,11-bis(methoxycarbonyl)-3-methyl-13-phenylsulfonylbicyclo[7.4.0]trideca-1⁽¹³⁾,2,8-triene

Base Information

• Chemical Name: (2Z,8Z)-11,11-bis(methoxycarbonyl)-3-methyl-13-phenylsulfonylbicyclo[7.4.0]trideca-1⁽¹³⁾,2,8-triene
• CAS No.: 1414368-48-1
• Molecular Formula: C₂₄H₂₈O₆S
• Molecular Weight: 444.549

Synonyms:(2Z,8Z)-11,11-bis(methoxycarbonyl)-3-methyl-13-phenylsulfonylbicyclo[7.4.0]trideca-1⁽¹³⁾,2,8-triene

Chemical Property of (2Z,8Z)-11,11-bis(methoxycarbonyl)-3-methyl-13-phenylsulfonylbicyclo[7.4.0]trideca-1⁽¹³⁾,2,8-triene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2Z,8Z)-11,11-bis(methoxycarbonyl)-3-methyl-13-phenylsulfonylbicyclo[7.4.0]trideca-1⁽¹³⁾,2,8-triene

There total 8 articles about (2Z,8Z)-11,11-bis(methoxycarbonyl)-3-methyl-13-phenylsulfonylbicyclo[7.4.0]trideca-1⁽¹³⁾,2,8-triene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

dimethyl 2-[4-(1-methylcyclopentyl)-2-phenylsulfonyl-2,3-butadienyl]-2-(prop-2-ynyl)malonate (1414368-29-8) → (2Z,8Z)-11,11-bis(methoxycarbonyl)-3-methyl-13-phenylsulfonylbicyclo[7.4.0]trideca-1(13),2,8-triene (1414368-48-1)

Guidance literature:

With tris(triphenylphosphine)rhodium(l) chloride; In toluene; at 80 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/ja309830p

Reference yield:

dimethyl 2-[4-hydroxy-4-(1-methylcyclopentyl)but-2-ynyl]-2-(prop-2-ynyl)malonate (1414368-07-2) → (2Z,8Z)-11,11-bis(methoxycarbonyl)-3-methyl-13-phenylsulfonylbicyclo[7.4.0]trideca-1(13),2,8-triene (1414368-48-1)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3: tris(triphenylphosphine)rhodium(l) chloride / toluene / 0.5 h / 80 °C / Inert atmosphere

With tris(triphenylphosphine)rhodium(l) chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1021/ja309830p

Reference yield:

dimethyl 2,2-di(prop-2-ynyl)malonate (63104-44-9) → (2Z,8Z)-11,11-bis(methoxycarbonyl)-3-methyl-13-phenylsulfonylbicyclo[7.4.0]trideca-1(13),2,8-triene (1414368-48-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 0.08 h / -78 °C / Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

4.1: tris(triphenylphosphine)rhodium(l) chloride / toluene / 0.5 h / 80 °C / Inert atmosphere

With tris(triphenylphosphine)rhodium(l) chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1021/ja309830p

upstream raw materials:

dimethyl 2-[4-(1-methylcyclopentyl)-2-phenylsulfonyl-2,3-butadienyl]-2-(prop-2-ynyl)malonate

dimethyl 2,2-di(prop-2-ynyl)malonate

dimethyl 2-[4-hydroxy-4-(1-methylcyclopentyl)but-2-ynyl]-2-(prop-2-ynyl)malonate

1-methyl-1-cyclopentanecarbaldehyde

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1414368-48-1 (2Z,8Z)-11,11-bis(methoxycarbonyl)-3-methyl-13-phenylsulfonylbicyclo[7.4.0]trideca-1⁽¹³⁾,2,8-triene

Send

Send

Metric Ton KG G Pound L ML

Send

Send