5-(3-(6-(isopropylamino)pyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,2,4-thiadiazol-3-amine

Base Information

Chemical Name:5-(3-(6-(isopropylamino)pyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,2,4-thiadiazol-3-amine
CAS No.:1401349-77-6
Molecular Formula:C₂₄H₂₃N₇O₂S₂
Molecular Weight:505.624
Hs Code.:

Synonyms:5-(3-(6-(isopropylamino)pyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,2,4-thiadiazol-3-amine

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Chemical Property of 5-(3-(6-(isopropylamino)pyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,2,4-thiadiazol-3-amine

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Technology Process of 5-(3-(6-(isopropylamino)pyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,2,4-thiadiazol-3-amine

There total 8 articles about 5-(3-(6-(isopropylamino)pyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,2,4-thiadiazol-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1401349-76-5
5-(3-(6-(isopropylamino)pyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,2,4-thiadiazol-3-amine

: 1401349-77-6
5-(3-(6-(isopropylamino)pyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,2,4-thiadiazol-3-amine

Guidance literature:: With trifluoroacetic acid; at 100 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 269410-24-4
5-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole

: 1401349-77-6
5-(3-(6-(isopropylamino)pyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,2,4-thiadiazol-3-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 6 h / 85 °C / Inert atmosphere

2.1: dimethyl sulfoxide / 12 h / 110 °C

3.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

4.2: 2 h / 20 °C

5.1: copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 90 °C / Inert atmosphere

6.1: trifluoroacetic acid / 0.5 h / 100 °C / Microwave irradiation

With copper(l) iodide; iodine; sodium hydride; potassium carbonate; trifluoroacetic acid; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1401349-68-5
3-chloro-5-(1H-indol-5-yl)-1,2,4-thiadiazole

: 1401349-77-6
5-(3-(6-(isopropylamino)pyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,2,4-thiadiazol-3-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: dimethyl sulfoxide / 12 h / 110 °C

2.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

3.2: 2 h / 20 °C

4.1: copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 90 °C / Inert atmosphere

5.1: trifluoroacetic acid / 0.5 h / 100 °C / Microwave irradiation

With copper(l) iodide; iodine; sodium hydride; trifluoroacetic acid; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;