(S)-N₁-(7-bromo-6-methyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-phenylpropane-1,2-diamine

Base Information

• Chemical Name: (S)-N₁-(7-bromo-6-methyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-phenylpropane-1,2-diamine
• CAS No.: 1438883-28-3
• Molecular Formula: C₂₁H₂₀BrN₅S
• Molecular Weight: 454.393

Synonyms:(S)-N₁-(7-bromo-6-methyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-phenylpropane-1,2-diamine

Chemical Property of (S)-N₁-(7-bromo-6-methyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-phenylpropane-1,2-diamine

Chemical Property:

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Technology Process of (S)-N₁-(7-bromo-6-methyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-phenylpropane-1,2-diamine

There total 5 articles about (S)-N₁-(7-bromo-6-methyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-phenylpropane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4,6-triisopropylbenzenesulfonic acid 7-bromo-6-methyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl ester (1438887-46-7) + (2S)-3-phenylpropane-1,2-diamine (85612-60-8) → (S)-N1-(7-bromo-6-methyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-phenylpropane-1,2-diamine (1438883-28-3)

Guidance literature:

With triethylamine; In N,N-dimethyl acetamide; at 20 ℃; for 2h;

Reference yield:

pyridine-4-carbonitrile (100-48-1) → (S)-N1-(7-bromo-6-methyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-phenylpropane-1,2-diamine (1438883-28-3)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium 2,2-dimethyl-1-propanolate / 1,4-dioxane; toluene / 20 °C

2: acetic acid; bromine / chloroform / 0 - 20 °C

3: triethylamine; dmap / dichloromethane / 1 h

4: triethylamine / N,N-dimethyl acetamide / 2 h / 20 °C

With dmap; bromine; potassium 2,2-dimethyl-1-propanolate; acetic acid; triethylamine; In 1,4-dioxane; dichloromethane; chloroform; N,N-dimethyl acetamide; toluene;

Reference yield:

7-bromo-6-methyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-ol (1438887-40-1) → (S)-N1-(7-bromo-6-methyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-phenylpropane-1,2-diamine (1438883-28-3)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; dmap / dichloromethane / 1 h

2: triethylamine / N,N-dimethyl acetamide / 2 h / 20 °C

With dmap; triethylamine; In dichloromethane; N,N-dimethyl acetamide;

upstream raw materials:

2,4,6-triisopropylbenzenesulfonic acid 7-bromo-6-methyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl ester

(2S)-3-phenylpropane-1,2-diamine

pyridine-4-carbonitrile

6-methyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-ol

Downstream raw materials:

(S)-N₁-[6-methyl-7-(2H-pyrazol-3-yl)-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl]-3-phenylpropane-1,2-diamine

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