5-(N,N-diethylamino)-1-(4-methoxyphenyl)-1-cyanopentane

Base Information

• Chemical Name: 5-(N,N-diethylamino)-1-(4-methoxyphenyl)-1-cyanopentane
• CAS No.: 203513-84-2
• Molecular Formula: C₁₇H₂₆N₂O
• Molecular Weight: 274.406
• Mol file: 203513-84-2.mol

Synonyms:5-(N,N-diethylamino)-1-(4-methoxyphenyl)-1-cyanopentane

Chemical Property of 5-(N,N-diethylamino)-1-(4-methoxyphenyl)-1-cyanopentane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 5-(N,N-diethylamino)-1-(4-methoxyphenyl)-1-cyanopentane

There total 1 articles about 5-(N,N-diethylamino)-1-(4-methoxyphenyl)-1-cyanopentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.5%

5-(N,N-diethylamino)-1-carboethoxy-1-(methoxyphenyl)-1-cyanopentane → 5-(N,N-diethylamino)-1-(4-methoxyphenyl)-1-cyanopentane (203513-84-2)

Guidance literature:

With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In water; benzene; at 79 ℃; for 1h;

DOI:10.1007/BF02464670

Reference yield: 72.8%

5-(N,N-diethylamino)-1-(4-methoxyphenyl)-1-cyanopentane (203513-84-2) → (+/-)-6-diethylamino-2-(4-methoxyphenyl)hexanamide (271577-46-9)

Guidance literature:

With potassium hydroxide; dihydrogen peroxide; In dimethyl sulfoxide; at 20 ℃; for 6h;

DOI:10.1016/S0223-5234(00)00116-1

Reference yield:

5-(N,N-diethylamino)-1-(4-methoxyphenyl)-1-cyanopentane (203513-84-2) → (+/-)-N-[5-(diethylamino)-1-(4-hydroxyphenyl)pentyl]-4-nitrobenzamide

Guidance literature:

Multi-step reaction with 5 steps

1: 72.8 percent / aq. H₂O₂; KOH / dimethylsulfoxide / 6 h / 20 °C

2: Br₂; NaOMe / Heating

3: 92.4 percent / aq. NaOH / (Et₃NCH₂Ph)Cl / ethanol / 5 h / Heating

4: 96.6 percent / acetonitrile / 0 - 5 °C

5: BBr₃ / CH₂Cl₂ / 5 h / -70 - 20 °C

With potassium hydroxide; sodium hydroxide; dihydrogen peroxide; bromine; sodium methylate; boron tribromide; N-benzyl-N,N,N-triethylammonium chloride; In ethanol; dichloromethane; dimethyl sulfoxide; acetonitrile; 1: Addition / 2: modified Hofmann rearrangement / 3: Decarboxylation / 4: Condensation / 5: demethylation; ether cleavage;

DOI:10.1016/S0223-5234(00)00116-1

Downstream raw materials:

(+/-)-6-diethylamino-2-(4-methoxyphenyl)hexanamide

(+/-)-1-amino-5-diethylamino-1-(4-methoxyphenyl)pentane

(+/-)-methyl N-[5-diethylamino-1-(4-methoxyphenyl)pentyl]carbamate