2-(2,4,6-Trifluorophenyl)ethan-1-amine

Base Information

Chemical Name:2-(2,4,6-Trifluorophenyl)ethan-1-amine
CAS No.:771580-16-6
Molecular Formula:C₈H₈F₃N
Molecular Weight:175.153
Hs Code.:
DSSTox Substance ID:DTXSID001302124

Synonyms:2-(2,4,6-trifluorophenyl)ethan-1-amine;771580-16-6;SCHEMBL15819455;2,4,6-Trifluorobenzeneethanamine;DTXSID001302124;AKOS006293561;EN300-1857373

Suppliers and Price of 2-(2,4,6-Trifluorophenyl)ethan-1-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2-(2,4,6-Trifluorophenyl)ethan-1-amine

Chemical Property:

XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:175.06088375
Heavy Atom Count:12
Complexity:130

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=C(C=C(C(=C1F)CCN)F)F

Technology Process of 2-(2,4,6-Trifluorophenyl)ethan-1-amine

There total 4 articles about 2-(2,4,6-Trifluorophenyl)ethan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 220227-80-5
2-(2,4,6-trifluorophenyl)acetonitrile

: 771580-16-6
2-(2,4,6-trifluorophenyl)ethan-1-amine

Guidance literature:: With aluminum (III) chloride; lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/acs.jmedchem.1c01432

Reference yield:

: 1027200-34-5
1,3,5-Trifluoro-2-((E)-2-nitro-vinyl)-benzene

: 771580-16-6
2-(2,4,6-trifluorophenyl)ethan-1-amine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating;
DOI:10.1021/jm950639r

Reference yield:

: 372-38-3
1,3,5-trifluorobenzene

: 771580-16-6
2-(2,4,6-trifluorophenyl)ethan-1-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) BuLi / 1.) hexane, THF, -65 degC, 0.5 h, 2.) hexane, THF, from -65 deg C to RT

2: 1.) NaOH, 2.) 4N aq. HCl / 1.) H₂O, methanol, -3 deg C, 15 min

3: LiAlH₄ / tetrahydrofuran / 2 h / Heating

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; In tetrahydrofuran;
DOI:10.1021/jm950639r