N-[3-methyl-4-(2-morpholino-2-thioxo-ethyl)phenyl]acetamide

Base Information

• Chemical Name: N-[3-methyl-4-(2-morpholino-2-thioxo-ethyl)phenyl]acetamide
• CAS No.: 34956-30-4
• Molecular Formula: C₁₅H₂₀N₂O₂S
• Molecular Weight: 292.402
• Mol file: 34956-30-4.mol

Synonyms:N-(3-methyl-4-(2-(4-morpholinyl)-2-thioxoethyl)phenyl)acetamide

Chemical Property of N-[3-methyl-4-(2-morpholino-2-thioxo-ethyl)phenyl]acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[3-methyl-4-(2-morpholino-2-thioxo-ethyl)phenyl]acetamide

There total 2 articles about N-[3-methyl-4-(2-morpholino-2-thioxo-ethyl)phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

morpholine (110-91-8,99108-56-2) + N-(4-acetyl-3-methylphenyl)acetamide (34956-31-5) → N-(3-methyl-4-(2-(4-morpholinyl)-2-thioxoethyl)phenyl)acetamide (34956-30-4)

Guidance literature:

With sulfur; at 135 ℃; for 6h; Inert atmosphere;

DOI:10.1016/j.bmc.2018.07.017

Reference yield:

→ N-(3-methyl-4-(2-(4-morpholinyl)-2-thioxoethyl)phenyl)acetamide (34956-30-4)

Guidance literature:

4-CH3CO-3-CH3-acetanilid, Morpholin, S;

Reference yield: 70.3%

N-(3-methyl-4-(2-(4-morpholinyl)-2-thioxoethyl)phenyl)acetamide (34956-30-4) → 2-(4-amino-2-methylphenyl)acetic acid (34841-55-9)

Guidance literature:

N-(3-methyl-4-(2-(4-morpholinyl)-2-thioxoethyl)phenyl)acetamide; With hydrogenchloride; water; at 100 - 110 ℃; for 48h;

With sodium hydroxide; In water; pH=9 - 10;

With hydrogenchloride; In water; pH=5;

upstream raw materials:

morpholine

N-(4-acetyl-3-methylphenyl)acetamide

Downstream raw materials:

2-(4-amino-2-methylphenyl)acetic acid