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Technology Process of Ent-Oridonin

Ent-Oridonin

Base Information
  • Chemical Name:Ent-Oridonin
  • CAS No.:28957-04-2
  • Molecular Formula:C20H28O6
  • Molecular Weight:364.439
  • Hs Code.:29389090
  • European Community (EC) Number:631-100-8
  • ChEMBL ID:CHEMBL454570
  • Metabolomics Workbench ID:135334
Ent-Oridonin

Synonyms:lasidonin;oridonin;oridonin, (1alpha,5alpha,6alpha,7beta,8beta,9alpha,10beta,13beta,14S)-isomer;oridonin, (1alpha,6beta,7alpha,11alpha)-isomer;oridonin, (1alpha,6beta,7alpha,11beta)-isomer

Suppliers and Price of Ent-Oridonin
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • Oridonin
  • 50mg
  • $ 382.00
  • Usbiological
  • Oridonin
  • 20mg
  • $ 305.00
  • TRC
  • Oridonin
  • 10mg
  • $ 120.00
  • Sigma-Aldrich
  • Oridonin ≥98% (HPLC)
  • 5mg
  • $ 119.00
  • Sigma-Aldrich
  • Oridonin
  • 5mg
  • $ 115.00
  • Sigma-Aldrich
  • Oridonin ≥98% (HPLC)
  • 25mg
  • $ 471.00
  • Medical Isotopes, Inc.
  • Oridonin
  • 100 mg
  • $ 1460.00
  • Labseeker
  • RUBESCENSINA 95
  • 20g
  • $ 2567.00
  • Labseeker
  • RUBESCENSINA 95
  • 10g
  • $ 1467.00
  • Labseeker
  • RUBESCENSINA 95
  • 1g
  • $ 417.00
Total 140 raw suppliers
Chemical Property of Ent-Oridonin
Chemical Property:
  • Appearance/Colour:powder 
  • Vapor Pressure:6.9E-17mmHg at 25°C 
  • Melting Point:248-250 °C 
  • Refractive Index:1.635 
  • Boiling Point:599.8 °C at 760 mmHg 
  • PKA:10.96±0.70(Predicted) 
  • Flash Point:215 °C 
  • PSA：107.22000 
  • Density:1.42 g/cm3 
  • LogP:0.37560 
  • Storage Temp.:2-8°C 
  • Solubility.:DMSO: >20mg/mL 
  • XLogP3:0.1
  • Hydrogen Bond Donor Count:4
  • Hydrogen Bond Acceptor Count:6
  • Rotatable Bond Count:0
  • Exact Mass:364.18858861
  • Heavy Atom Count:26
  • Complexity:717
Purity/Quality:

more than 97% *data from raw suppliers

Oridonin *data from reagent suppliers

Safty Information:
  • Pictogram(s): Xn 
  • Hazard Codes:Xn 
  • Statements: 40 
  • Safety Statements: 36/37-24/25 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC1(CCC(C23C1C(C(C45C2CCC(C4O)C(=C)C5=O)(OC3)O)O)O)C
  • Isomeric SMILES:CC1(CC[C@@H]([C@]23[C@@H]1[C@@H]([C@@]([C@]45[C@H]2CC[C@H]([C@H]4O)C(=C)C5=O)(OC3)O)O)O)C
  • Recent ClinicalTrials:Effect of Inflammasome Inhibitor on hsCRP in Patients After PCI
  • Description Oridonin is a diterpenoid that has been found in R. rubescens and has anti-inflammatory and anticancer properties. It is an inhibitor of AKT1 and AKT2 (IC50s = 8.4 and 8.9 μM, respectively). Oridonin inhibits proliferation of KYSE70, KYSE410, and KYSE450 esophageal cancer cells in a dose-dependent manner, halts the cell cycle at the G2/M phase, and induces apoptosis when used at a concentration of 20 μM. It decreases the expression of cleaved poly(ADP-ribose) polymerase (PARP), caspase-3, caspase-7, and Bims and the protein levels of phosphorylated AKT and reduces AKT activity. Oridonin reduces tumor growth in patient-derived mouse tumor models when administered at doses of 40 and 160 mg/kg. Oridonin is also an inhibitor of NLRP3 inflammasome assembly and activation. It inhibits inflammation in wild-type, but not Nlrp3-/-, mice in a model of high-fat diet-induced type 2 diabetes when administered at a dose of 3 mg/kg.
  • Uses Oridonin is an effective anticancer agent due to its ability to inhibit proliferation and induce apoptosis of human osteosarcoma cells. Blocks Wnt/β-catenin signalling.
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