(S,1R,1'R,2Z,2'Z)-[1,1'-biphenyl]-4,4'-diylbis(2-oxoethane-2,1-diyl)bis(2-((S)-1-fluoro-2-((methoxycarbonyl)amino)-3-methylbutylidene)cyclopentanecarboxylate)acid

Base Information

Chemical Name:(S,1R,1'R,2Z,2'Z)-[1,1'-biphenyl]-4,4'-diylbis(2-oxoethane-2,1-diyl)bis(2-((S)-1-fluoro-2-((methoxycarbonyl)amino)-3-methylbutylidene)cyclopentanecarboxylate)acid
CAS No.:1374036-17-5
Molecular Formula:C₄₂H₅₀F₂N₂O₁₀
Molecular Weight:780.863
Hs Code.:

(S,1R,1'R,2Z,2'Z)-[1,1'-biphenyl]-4,4'-diylbis(2-oxoethane-2,1-diyl)bis(2-((S)-1-fluoro-2-((methoxycarbonyl)amino)-3-methylbutylidene)cyclopentanecarboxylate)acid

Synonyms:(S,1R,1'R,2Z,2'Z)-[1,1'-biphenyl]-4,4'-diylbis(2-oxoethane-2,1-diyl)bis(2-((S)-1-fluoro-2-((methoxycarbonyl)amino)-3-methylbutylidene)cyclopentanecarboxylate)acid

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Chemical Property of (S,1R,1'R,2Z,2'Z)-[1,1'-biphenyl]-4,4'-diylbis(2-oxoethane-2,1-diyl)bis(2-((S)-1-fluoro-2-((methoxycarbonyl)amino)-3-methylbutylidene)cyclopentanecarboxylate)acid

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Technology Process of (S,1R,1'R,2Z,2'Z)-[1,1'-biphenyl]-4,4'-diylbis(2-oxoethane-2,1-diyl)bis(2-((S)-1-fluoro-2-((methoxycarbonyl)amino)-3-methylbutylidene)cyclopentanecarboxylate)acid

There total 9 articles about (S,1R,1'R,2Z,2'Z)-[1,1'-biphenyl]-4,4'-diylbis(2-oxoethane-2,1-diyl)bis(2-((S)-1-fluoro-2-((methoxycarbonyl)amino)-3-methylbutylidene)cyclopentanecarboxylate)acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 4072-67-7
4,4'-bis(bromoacetyl)biphenyl

: 1374036-16-4
(R,Z)-2-((S)-1-fluoro-2-((methoxycarbonyl)amino)-3-methylbutylidene)cyclopentanecarboxylic acid

: 1374036-17-5
(S,1R,1'R,2Z,2'Z)-[1,1'-biphenyl]-4,4'-diylbis(2-oxoethane-2,1-diyl)bis(2-((S)-1-fluoro-2-((methoxycarbonyl)amino)-3-methylbutylidene)cyclopentanecarboxylate)acid

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 3h;
DOI:10.1016/j.bmcl.2012.02.051

Reference yield:

: C₂₄H₃₁FO₂Si

: 1374036-17-5
(S,1R,1'R,2Z,2'Z)-[1,1'-biphenyl]-4,4'-diylbis(2-oxoethane-2,1-diyl)bis(2-((S)-1-fluoro-2-((methoxycarbonyl)amino)-3-methylbutylidene)cyclopentanecarboxylate)acid

Guidance literature:: Multi-step reaction with 7 steps

1: Dess-Martin periodane / dichloromethane / 4 h / 20 °C

2: titanium(IV) tetraethanolate / tetrahydrofuran; isopropyl alcohol / 4 h / 20 °C

3: toluene; pentane / 1 h / -78 °C

4: hydrogenchloride; ethanol / 1,4-dioxane / 16 h / 20 °C

5: triethylamine / ethanol; dichloromethane / 2 h / -10 °C

6: chromium(VI) oxide; sulfuric acid; water / acetone / 1 h / 0 °C

7: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h

With chromium(VI) oxide; hydrogenchloride; titanium(IV) tetraethanolate; ethanol; sulfuric acid; water; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; isopropyl alcohol; acetone; toluene; acetonitrile; pentane; 1: Dess-Martin oxidation / 6: Jones oxidation;
DOI:10.1016/j.bmcl.2012.02.051

Reference yield:

: 1374036-12-0
(R,E)-N-((Z)-2-((R)-2-(((tert-butyldiphenylsilyl)oxy)methyl)cyclopentylidene)-2-fluoroethylidene)-2-methylpropane-2-sulfinamide

: 1374036-17-5
(S,1R,1'R,2Z,2'Z)-[1,1'-biphenyl]-4,4'-diylbis(2-oxoethane-2,1-diyl)bis(2-((S)-1-fluoro-2-((methoxycarbonyl)amino)-3-methylbutylidene)cyclopentanecarboxylate)acid

Guidance literature:: Multi-step reaction with 5 steps

1: toluene; pentane / 1 h / -78 °C

2: hydrogenchloride; ethanol / 1,4-dioxane / 16 h / 20 °C

3: triethylamine / ethanol; dichloromethane / 2 h / -10 °C

4: chromium(VI) oxide; sulfuric acid; water / acetone / 1 h / 0 °C

5: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h

With chromium(VI) oxide; hydrogenchloride; ethanol; sulfuric acid; water; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane; acetone; toluene; acetonitrile; pentane; 4: Jones oxidation;
DOI:10.1016/j.bmcl.2012.02.051