(+)-methyl (S)-2-[1-allyl-4-(4-methoxybenzyl)-3,6-dioxopiperazin-2-yl]acetate

Base Information

Chemical Name:(+)-methyl (S)-2-[1-allyl-4-(4-methoxybenzyl)-3,6-dioxopiperazin-2-yl]acetate
CAS No.:1160747-77-2
Molecular Formula:C₁₈H₂₂N₂O₅
Molecular Weight:346.383
Hs Code.:

Synonyms:(+)-methyl (S)-2-[1-allyl-4-(4-methoxybenzyl)-3,6-dioxopiperazin-2-yl]acetate

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Chemical Property of (+)-methyl (S)-2-[1-allyl-4-(4-methoxybenzyl)-3,6-dioxopiperazin-2-yl]acetate

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Technology Process of (+)-methyl (S)-2-[1-allyl-4-(4-methoxybenzyl)-3,6-dioxopiperazin-2-yl]acetate

There total 2 articles about (+)-methyl (S)-2-[1-allyl-4-(4-methoxybenzyl)-3,6-dioxopiperazin-2-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76385-50-7
(+)-dimethyl (S)-2-(2-chloroacetylamino)succinate

: 1160747-77-2
(+)-methyl (S)-2-[1-allyl-4-(4-methoxybenzyl)-3,6-dioxopiperazin-2-yl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetra-(n-butyl)ammonium iodide; triethylamine / acetonitrile / 48 h / Reflux; Inert atmosphere

2.1: tetra-(n-butyl)ammonium iodide; sodium hexamethyldisilazane / tetrahydrofuran / 0.67 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

With sodium hexamethyldisilazane; tetra-(n-butyl)ammonium iodide; triethylamine; In tetrahydrofuran; acetonitrile;
DOI:10.1039/c2md20070h

Reference yield:

: 6384-18-5
L-Aspartic acid dimethyl ester

: 1160747-77-2
(+)-methyl (S)-2-[1-allyl-4-(4-methoxybenzyl)-3,6-dioxopiperazin-2-yl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / dichloromethane / 16 h / 20 °C / Inert atmosphere

2.1: tetra-(n-butyl)ammonium iodide; triethylamine / acetonitrile / 48 h / Reflux; Inert atmosphere

3.1: tetra-(n-butyl)ammonium iodide; sodium hexamethyldisilazane / tetrahydrofuran / 0.67 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

With sodium hexamethyldisilazane; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1039/c2md20070h

Reference yield: 65.0%

: 1160747-77-2
(+)-methyl (S)-2-[1-allyl-4-(4-methoxybenzyl)-3,6-dioxopiperazin-2-yl]acetate

: (+)-(S)-2-[1-allyl-4-(4-methoxybenzyl)piperazin-2-yl]-ethanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 16h; Inert atmosphere; Reflux;
DOI:10.1039/c2md20070h