9-[2-(methoxycarbonylethyl)benzoyl]-3,4-dimethyl-7,8-diethyl-dipyrrinone

Base Information

• Chemical Name: 9-[2-(methoxycarbonylethyl)benzoyl]-3,4-dimethyl-7,8-diethyl-dipyrrinone
• CAS No.: 270928-59-1
• Molecular Formula: C₂₆H₃₀N₂O₄
• Molecular Weight: 434.535
• Mol file: 270928-59-1.mol

Synonyms:9-[2-(methoxycarbonylethyl)benzoyl]-3,4-dimethyl-7,8-diethyl-dipyrrinone

Chemical Property of 9-[2-(methoxycarbonylethyl)benzoyl]-3,4-dimethyl-7,8-diethyl-dipyrrinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-[2-(methoxycarbonylethyl)benzoyl]-3,4-dimethyl-7,8-diethyl-dipyrrinone

There total 3 articles about 9-[2-(methoxycarbonylethyl)benzoyl]-3,4-dimethyl-7,8-diethyl-dipyrrinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

3-(2-Chlorocarbonyl-phenyl)-propionic acid methyl ester (204995-04-0) + (4Z)-7,8-diethyl-2,3-dimethyl-(9H)-dipyrrin-1-one (270928-62-6) → 9-[2-(methoxycarbonylethyl)benzoyl]-3,4-dimethyl-7,8-diethyl-dipyrrinone (270928-59-1)

Guidance literature:

With tin(IV) chloride; In dichloromethane; at 20 ℃; for 1.5h;

DOI:10.1016/S0040-4020(00)00087-9

Reference yield:

ethyl 3,4-diethyl-5-formyl-1H-pyrrole-2-carboxylate (100370-73-8) → 9-[2-(methoxycarbonylethyl)benzoyl]-3,4-dimethyl-7,8-diethyl-dipyrrinone (270928-59-1)

Guidance literature:

Multi-step reaction with 3 steps

1: KOH / methanol; H₂O / 4 h / Heating

2: 2.1 g / AcOK; AcONa*3H₂O / 0.17 h / 160 °C

3: 59 percent / SnCl₄ / CH₂Cl₂ / 1.5 h / 20 °C

With potassium hydroxide; potassium acetate; sodium acetate; tin(IV) chloride; In methanol; dichloromethane; water; 1: Condensation / 2: Decarboxylation / 3: Acylation;

DOI:10.1016/S0040-4020(00)00087-9

Reference yield:

2,3-dimethyl-7,8-diethyl-10H-dipyrrin-1-one-9-carboxylic acid (270928-63-7) → 9-[2-(methoxycarbonylethyl)benzoyl]-3,4-dimethyl-7,8-diethyl-dipyrrinone (270928-59-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.1 g / AcOK; AcONa*3H₂O / 0.17 h / 160 °C

2: 59 percent / SnCl₄ / CH₂Cl₂ / 1.5 h / 20 °C

With potassium acetate; sodium acetate; tin(IV) chloride; In dichloromethane; 1: Decarboxylation / 2: Acylation;

DOI:10.1016/S0040-4020(00)00087-9

upstream raw materials:

3-(2-Chlorocarbonyl-phenyl)-propionic acid methyl ester

(4Z)-7,8-diethyl-2,3-dimethyl-(9H)-dipyrrin-1-one

ethyl 3,4-diethyl-5-formyl-1H-pyrrole-2-carboxylate

2,3-dimethyl-7,8-diethyl-10H-dipyrrin-1-one-9-carboxylic acid

Downstream raw materials:

9-[2-(carboxyethyl)benzyl]-3,4-dimethyl-7,8-diethyl-dipyrrinone

9-[2-(carboxyethyl)benzoyl]-3,4-dimethyl-7,8-diethyl-dipyrrinone