2-(3-phenoxybenzyl)-5-(2-(piperidin-1-yl)ethyl)-1,2,5-thiadiazolidine 1,1-dioxide

Base Information

Chemical Name:2-(3-phenoxybenzyl)-5-(2-(piperidin-1-yl)ethyl)-1,2,5-thiadiazolidine 1,1-dioxide
CAS No.:1341127-09-0
Molecular Formula:C₂₂H₂₉N₃O₃S
Molecular Weight:415.557
Hs Code.:

Synonyms:2-(3-phenoxybenzyl)-5-(2-(piperidin-1-yl)ethyl)-1,2,5-thiadiazolidine 1,1-dioxide

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Chemical Property of 2-(3-phenoxybenzyl)-5-(2-(piperidin-1-yl)ethyl)-1,2,5-thiadiazolidine 1,1-dioxide

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Technology Process of 2-(3-phenoxybenzyl)-5-(2-(piperidin-1-yl)ethyl)-1,2,5-thiadiazolidine 1,1-dioxide

There total 6 articles about 2-(3-phenoxybenzyl)-5-(2-(piperidin-1-yl)ethyl)-1,2,5-thiadiazolidine 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 110-89-4
piperidine

: 1341127-10-3
2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl methanesulfonate

: 1341127-09-0
2-(3-phenoxybenzyl)-5-(2-(piperidin-1-yl)ethyl)-1,2,5-thiadiazolidine 1,1-dioxide

Guidance literature:: With sodium hydrogencarbonate; In ethanol; Reflux;
DOI:10.1016/j.bmc.2011.08.054

Reference yield:

: 1341126-59-7
2-(3-phenoxybenzyl)-1,2,5-thiadiazolidine 1,1-dioxide

: 1341127-09-0
2-(3-phenoxybenzyl)-5-(2-(piperidin-1-yl)ethyl)-1,2,5-thiadiazolidine 1,1-dioxide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 20 °C

2.1: lithium borohydride; ethanol / tetrahydrofuran / 20 °C

2.2: pH 4

3.1: triethylamine / dichloromethane / 0 - 20 °C

4.1: sodium hydrogencarbonate / ethanol / Reflux

With lithium borohydride; ethanol; sodium hydride; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.08.054

Reference yield:

: 1341126-95-1
methyl [5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]acetate

: 1341127-09-0
2-(3-phenoxybenzyl)-5-(2-(piperidin-1-yl)ethyl)-1,2,5-thiadiazolidine 1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium borohydride; ethanol / tetrahydrofuran / 20 °C

1.2: pH 4

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: sodium hydrogencarbonate / ethanol / Reflux

With lithium borohydride; ethanol; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.bmc.2011.08.054