(pivaloyloxy)methyl 6α-<1(R)-<<<(p-nitrobenzyl)oxy>carbonyl>oxy>ethyl>-1-oxopenicillanate

Base Information

Chemical Name:(pivaloyloxy)methyl 6α-<1(R)-<<<(p-nitrobenzyl)oxy>carbonyl>oxy>ethyl>-1-oxopenicillanate
CAS No.:124093-84-1
Molecular Formula:C₂₄H₃₀N₂O₁₁S
Molecular Weight:554.575
Hs Code.:

Synonyms:(pivaloyloxy)methyl 6α-<1(R)-<<<(p-nitrobenzyl)oxy>carbonyl>oxy>ethyl>-1-oxopenicillanate

Suppliers and Price of (pivaloyloxy)methyl 6α-<1(R)-<<<(p-nitrobenzyl)oxy>carbonyl>oxy>ethyl>-1-oxopenicillanate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (pivaloyloxy)methyl 6α-<1(R)-<<<(p-nitrobenzyl)oxy>carbonyl>oxy>ethyl>-1-oxopenicillanate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (pivaloyloxy)methyl 6α-<1(R)-<<<(p-nitrobenzyl)oxy>carbonyl>oxy>ethyl>-1-oxopenicillanate

There total 6 articles about (pivaloyloxy)methyl 6α-<1(R)-<<<(p-nitrobenzyl)oxy>carbonyl>oxy>ethyl>-1-oxopenicillanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 124093-83-0
(pivaloyloxy)methyl 6α-<1(R)-<<<(p-nitrobenzyl)oxy>carbonyl>oxy>ethyl>penicillanate

: 124093-84-1
(pivaloyloxy)methyl 6α-<1(R)-<<<(p-nitrobenzyl)oxy>carbonyl>oxy>ethyl>-1-oxopenicillanate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 16h;
DOI:10.1021/jm00163a048

Reference yield:

: 18997-19-8
Chloromethyl pivalate

: 124093-84-1
(pivaloyloxy)methyl 6α-<1(R)-<<<(p-nitrobenzyl)oxy>carbonyl>oxy>ethyl>-1-oxopenicillanate

Guidance literature:: Multi-step reaction with 5 steps

1: 12.6 percent / Et₃N, KHCO₃ / dimethylformamide / 21 h / Ambient temperature

2: 1.) tert-BuMgCl, 2.) / 1.) THF, ether, -78 deg C, 1 h, 2.) -78 deg C, 1 h

3: 70 percent / H₂ / 10percent Pd/C / H₂O; tetrahydrofuran / 1.5 h

4: 97 percent / diisopropylethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 16 h / Ambient temperature

5: 50 percent / 80percent m-chloroperbenzoic acid / CH₂Cl₂ / 16 h / 0 °C

With dmap; tert-butylmagnesium chloride; hydrogen; potassium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00163a048

Reference yield:

: 69388-93-8
6,6-dibromopenicillanic acid pivaloyloxymethyl ester

: 124093-84-1
(pivaloyloxy)methyl 6α-<1(R)-<<<(p-nitrobenzyl)oxy>carbonyl>oxy>ethyl>-1-oxopenicillanate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) tert-BuMgCl, 2.) / 1.) THF, ether, -78 deg C, 1 h, 2.) -78 deg C, 1 h

2: 70 percent / H₂ / 10percent Pd/C / H₂O; tetrahydrofuran / 1.5 h

3: 97 percent / diisopropylethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 16 h / Ambient temperature

4: 50 percent / 80percent m-chloroperbenzoic acid / CH₂Cl₂ / 16 h / 0 °C

With dmap; tert-butylmagnesium chloride; hydrogen; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm00163a048