1-benzyl-5-(phenylsulfonyl)-5'-methyl-6-(3-benzyloxypropyl)-2-piperidinone

Base Information

Chemical Name:1-benzyl-5-(phenylsulfonyl)-5'-methyl-6-(3-benzyloxypropyl)-2-piperidinone
CAS No.:162379-22-8
Molecular Formula:C₂₉H₃₃NO₄S
Molecular Weight:491.651
Hs Code.:

Synonyms:1-benzyl-5-(phenylsulfonyl)-5'-methyl-6-(3-benzyloxypropyl)-2-piperidinone

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Chemical Property of 1-benzyl-5-(phenylsulfonyl)-5'-methyl-6-(3-benzyloxypropyl)-2-piperidinone

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Technology Process of 1-benzyl-5-(phenylsulfonyl)-5'-methyl-6-(3-benzyloxypropyl)-2-piperidinone

There total 5 articles about 1-benzyl-5-(phenylsulfonyl)-5'-methyl-6-(3-benzyloxypropyl)-2-piperidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 137710-72-6,137710-77-1
1-benzyl-5-(phenylsulfonyl)-6-(3-benzyloxypropyl)-2-piperidinone

: 77-78-1
dimethyl sulfate

: 162379-22-8
1-benzyl-5-(phenylsulfonyl)-5'-methyl-6-(3-benzyloxypropyl)-2-piperidinone

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; -78 deg C, 0.5 h, then RT;
DOI:10.1016/0040-4020(95)00036-8

Reference yield:

: 5470-84-8
4-benzyloxybutanal

: 162379-22-8
1-benzyl-5-(phenylsulfonyl)-5'-methyl-6-(3-benzyloxypropyl)-2-piperidinone

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / 2 h / Ambient temperature

2: 82 percent / 1.) boron trifluoride etherate, 2.) butyllithium, TFAA / tetrahydrofuran; hexane / 0.03 h / -78 °C

3: 91 percent / n-BuLi / tetrahydrofuran; hexane / -78 deg C, 0.5 h, then RT

With n-butyllithium; boron trifluoride diethyl etherate; trifluoroacetic anhydride; In tetrahydrofuran; hexane; toluene;
DOI:10.1016/0040-4020(95)00036-8

Reference yield:

: 4541-14-4
4-benzyloxy-butan-1-ol

: 162379-22-8
1-benzyl-5-(phenylsulfonyl)-5'-methyl-6-(3-benzyloxypropyl)-2-piperidinone

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / PDC / CH₂Cl₂ / 5 h

2: toluene / 2 h / Ambient temperature

3: 82 percent / 1.) boron trifluoride etherate, 2.) butyllithium, TFAA / tetrahydrofuran; hexane / 0.03 h / -78 °C

4: 91 percent / n-BuLi / tetrahydrofuran; hexane / -78 deg C, 0.5 h, then RT

With dipyridinium dichromate; n-butyllithium; boron trifluoride diethyl etherate; trifluoroacetic anhydride; In tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1016/0040-4020(95)00036-8