3α-benzoyloxy-8-(2-(3,5-dihydroxyphenyl)-2-oxoethyl)-8-azabicyclo[3.2.1]octane

Base Information

Chemical Name:3α-benzoyloxy-8-(2-(3,5-dihydroxyphenyl)-2-oxoethyl)-8-azabicyclo[3.2.1]octane
CAS No.:1361026-95-0
Molecular Formula:C₂₂H₂₃NO₅
Molecular Weight:381.428
Hs Code.:

Synonyms:3α-benzoyloxy-8-(2-(3,5-dihydroxyphenyl)-2-oxoethyl)-8-azabicyclo[3.2.1]octane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3α-benzoyloxy-8-(2-(3,5-dihydroxyphenyl)-2-oxoethyl)-8-azabicyclo[3.2.1]octane

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Technology Process of 3α-benzoyloxy-8-(2-(3,5-dihydroxyphenyl)-2-oxoethyl)-8-azabicyclo[3.2.1]octane

There total 2 articles about 3α-benzoyloxy-8-(2-(3,5-dihydroxyphenyl)-2-oxoethyl)-8-azabicyclo[3.2.1]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 62932-92-7
2-bromo-1-(3,5-dihydroxyphenyl)ethan-1-one

: 18470-33-2,20811-95-4,123202-90-4
Nortropacocaine

: 1361026-95-0
3α-benzoyloxy-8-(2-(3,5-dihydroxyphenyl)-2-oxoethyl)-8-azabicyclo[3.2.1]octane

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 2h; Darkness; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.12.008

Reference yield:

: 51863-60-6
3,5-dihydroxyacetophenone

: 1361026-95-0
3α-benzoyloxy-8-(2-(3,5-dihydroxyphenyl)-2-oxoethyl)-8-azabicyclo[3.2.1]octane

Guidance literature:: Multi-step reaction with 2 steps

1: copper(ll) bromide / dichloromethane; chloroform; ethyl acetate / 2 h / Reflux

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 20 °C / Darkness; Inert atmosphere

With N-ethyl-N,N-diisopropylamine; copper(ll) bromide; In dichloromethane; chloroform; ethyl acetate; acetonitrile;
DOI:10.1016/j.bmcl.2011.12.008