7-(4-ethylphenyl)-2,3-dihydro-1-benzothiepine-4-carboxylic acid 1,1-dioxide

Base Information

Chemical Name:7-(4-ethylphenyl)-2,3-dihydro-1-benzothiepine-4-carboxylic acid 1,1-dioxide
CAS No.:279261-36-8
Molecular Formula:C₁₉H₁₈O₄S
Molecular Weight:342.416
Hs Code.:

Synonyms:7-(4-ethylphenyl)-2,3-dihydro-1-benzothiepine-4-carboxylic acid 1,1-dioxide

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Chemical Property of 7-(4-ethylphenyl)-2,3-dihydro-1-benzothiepine-4-carboxylic acid 1,1-dioxide

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Technology Process of 7-(4-ethylphenyl)-2,3-dihydro-1-benzothiepine-4-carboxylic acid 1,1-dioxide

There total 8 articles about 7-(4-ethylphenyl)-2,3-dihydro-1-benzothiepine-4-carboxylic acid 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 279261-35-7
methyl 7-(4-ethylphenyl)-2,3-dihydro-1-benzothiepine-4-carboxylate 1,1-dioxide

: 279261-36-8
7-(4-ethylphenyl)-2,3-dihydro-1-benzothiepine-4-carboxylic acid 1,1-dioxide

Guidance literature:: With hydrogenchloride; In 1,2-dimethoxyethane; for 24h; Heating;
DOI:10.1248/cpb.52.577

Reference yield:

: 15084-55-6
7-bromo-3,4-dihydro-1-benzothiepin-5(2H)-one

: 279261-36-8
7-(4-ethylphenyl)-2,3-dihydro-1-benzothiepine-4-carboxylic acid 1,1-dioxide

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / sodium methoxide / 5 h / Heating

2: NaBH₄ / tetrahydrofuran; methanol / 1 h / -20 - -10 °C

3: Et₃N / tetrahydrofuran / 1.5 h / 0 - 20 °C

4: 37.2 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / 20 °C

5: 90 percent / aq. H₂O₂; acetic acid / 1 h / Heating

6: 85 percent / aq. K₂CO₃; Pd(PPh₃)4 / toluene; ethanol / 15 h / Heating

7: 87 percent / aq. HCl / 1,2-dimethoxy-ethane / 24 h / Heating

With hydrogenchloride; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dihydrogen peroxide; sodium methylate; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; toluene; 6: Suzuki coupling;
DOI:10.1248/cpb.52.577

Reference yield:

: 63139-21-9
4-ethylphenylboronic acid

: 279261-36-8
7-(4-ethylphenyl)-2,3-dihydro-1-benzothiepine-4-carboxylic acid 1,1-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / aq. K₂CO₃; Pd(PPh₃)4 / toluene; ethanol / 15 h / Heating

2: 87 percent / aq. HCl / 1,2-dimethoxy-ethane / 24 h / Heating

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; ethanol; toluene; 1: Suzuki coupling;
DOI:10.1248/cpb.52.577