methyl 4,6-bis-(tert-butyldimethylsilanyloxy)-3-chloro-2-[2-(4-methoxy-2,5-bis(methoxymethoxy)phenylcarbamoyl)ethyl]benzoate

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Chemical Name:methyl 4,6-bis-(tert-butyldimethylsilanyloxy)-3-chloro-2-[2-(4-methoxy-2,5-bis(methoxymethoxy)phenylcarbamoyl)ethyl]benzoate
CAS No.:811788-17-7
Molecular Formula:C₃₄H₅₄ClNO₁₀Si₂
Molecular Weight:728.427
Hs Code.:

Synonyms:methyl 4,6-bis-(tert-butyldimethylsilanyloxy)-3-chloro-2-[2-(4-methoxy-2,5-bis(methoxymethoxy)phenylcarbamoyl)ethyl]benzoate

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Chemical Property of methyl 4,6-bis-(tert-butyldimethylsilanyloxy)-3-chloro-2-[2-(4-methoxy-2,5-bis(methoxymethoxy)phenylcarbamoyl)ethyl]benzoate

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Technology Process of methyl 4,6-bis-(tert-butyldimethylsilanyloxy)-3-chloro-2-[2-(4-methoxy-2,5-bis(methoxymethoxy)phenylcarbamoyl)ethyl]benzoate

There total 8 articles about methyl 4,6-bis-(tert-butyldimethylsilanyloxy)-3-chloro-2-[2-(4-methoxy-2,5-bis(methoxymethoxy)phenylcarbamoyl)ethyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 811788-15-5
1-methoxy-2,5-bis(methoxymethoxy)-4-nitrobenzene

: 811788-17-7
methyl 4,6-bis-(tert-butyldimethylsilanyloxy)-3-chloro-2-[2-(4-methoxy-2,5-bis(methoxymethoxy)phenylcarbamoyl)ethyl]benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / H₂ / Pd/C / ethyl acetate / 4 h

2: 94 percent / EDC; DMAP / CH₂Cl₂ / 3 h / 25 °C

With dmap; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/ol048266o

Reference yield:

: 131223-60-4
2-methoxy-1,4-bis-methoxymethoxy-benzene

: 811788-17-7
methyl 4,6-bis-(tert-butyldimethylsilanyloxy)-3-chloro-2-[2-(4-methoxy-2,5-bis(methoxymethoxy)phenylcarbamoyl)ethyl]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 31 percent / ammonium nitrate; trifluoroacetic anhydride / tetrahydrofuran / 0.05 h / -10 °C

2: 99 percent / H₂ / Pd/C / ethyl acetate / 4 h

3: 94 percent / EDC; DMAP / CH₂Cl₂ / 3 h / 25 °C

With dmap; ammonium nitrate; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic anhydride; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/ol048266o

Reference yield:

: 811788-12-2
methyl 2-(but-3-enyl)-4,6-bis(tert-butyldimethylsilanyloxy)-3-chlorobenzoate

: 811788-17-7
methyl 4,6-bis-(tert-butyldimethylsilanyloxy)-3-chloro-2-[2-(4-methoxy-2,5-bis(methoxymethoxy)phenylcarbamoyl)ethyl]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: O₃ / methanol; CH₂Cl₂ / 0.25 h / -78 °C

1.2: 83 percent / PPh₃ / methanol; CH₂Cl₂ / 25 h / 2 °C

2.1: NaClO₂; NaH₂PO₄ / various solvent(s) / 25 °C

3.1: 94 percent / EDC; DMAP / CH₂Cl₂ / 3 h / 25 °C

With dmap; sodium chlorite; sodium dihydrogenphosphate; ozone; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In methanol; dichloromethane;
DOI:10.1021/ol048266o