2-((3-fluoro-4-(1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)ethynyl)quinoline

Base Information

Chemical Name:2-((3-fluoro-4-(1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)ethynyl)quinoline
CAS No.:1443361-83-8
Molecular Formula:C₂₆H₁₇FN₄
Molecular Weight:404.446
Hs Code.:

Synonyms:2-((3-fluoro-4-(1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)ethynyl)quinoline

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Chemical Property of 2-((3-fluoro-4-(1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)ethynyl)quinoline

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Technology Process of 2-((3-fluoro-4-(1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)ethynyl)quinoline

There total 7 articles about 2-((3-fluoro-4-(1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)ethynyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 2005-43-8
2-bromoquinoline

: 1443362-58-0
4-(3-(4-ethynyl-2-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridine

: 1443361-83-8
2-((3-fluoro-4-(1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)ethynyl)quinoline

Guidance literature:: 4-(3-(4-ethynyl-2-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridine; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In 1,4-dioxane; for 0.0833333h; Inert atmosphere;

2-bromoquinoline; In 1,4-dioxane; at 100 ℃; Inert atmosphere;

Reference yield:

: 1443362-57-9
4-(3-(2-fluoro-4-((trimethylsilyl)ethynyl)phenyl)-1-methyl-1H-pyrazol-4-yl)pyridine

: 1443361-83-8
2-((3-fluoro-4-(1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)ethynyl)quinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 1,4-dioxane / 0.08 h / Inert atmosphere

2.2: 100 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 1443362-56-8
4-(3-(4-bromo-2-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridine

: 1443361-83-8
2-((3-fluoro-4-(1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)ethynyl)quinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 1,4-dioxane / 0.08 h / Inert atmosphere

1.2: 100 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

3.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 1,4-dioxane / 0.08 h / Inert atmosphere

3.2: 100 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; 1,4-dioxane;