N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)ylidene]-2-fluoro-5-(trifluoromethyl)benzamide hydrochloride

Base Information

• Chemical Name: N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)ylidene]-2-fluoro-5-(trifluoromethyl)benzamide hydrochloride
• CAS No.: 1311285-18-3
• Molecular Formula: C₁₈H₁₅F₄N₃OS*ClH
• Molecular Weight: 433.857

Synonyms:N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)ylidene]-2-fluoro-5-(trifluoromethyl)benzamide hydrochloride

Chemical Property of N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)ylidene]-2-fluoro-5-(trifluoromethyl)benzamide hydrochloride

Chemical Property:

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Technology Process of N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)ylidene]-2-fluoro-5-(trifluoromethyl)benzamide hydrochloride

There total 2 articles about N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)ylidene]-2-fluoro-5-(trifluoromethyl)benzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-butyl-4-chloropyridin-3-amine (1311285-26-3) + 2-fluoro-5-(trifluoromethyl)benzoyl isothiocyanate (1311285-19-4) → N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)ylidene]-2-fluoro-5-(trifluoromethyl)benzamide hydrochloride (1311285-18-3)

Guidance literature:

In tetrahydrofuran; at 50 ℃;

Reference yield:

2-fluoro-5-(trifluoromethyl)benzoyl chloride (207981-46-2) → N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)ylidene]-2-fluoro-5-(trifluoromethyl)benzamide hydrochloride (1311285-18-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 5 h / 20 °C

2: tetrahydrofuran / 50 °C

In tetrahydrofuran;

Reference yield: 98.0%

N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)ylidene]-2-fluoro-5-(trifluoromethyl)benzamide hydrochloride (1311285-18-3) → N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-2-fluoro-5-(trifluoromethyl)benzamide (1231955-35-3)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; water; at 20 ℃; for 1h;

upstream raw materials:

2-fluoro-5-(trifluoromethyl)benzoyl chloride

N-butyl-4-chloropyridin-3-amine

2-fluoro-5-(trifluoromethyl)benzoyl isothiocyanate

Downstream raw materials:

N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-2-fluoro-5-(trifluoromethyl)benzamide

N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-2-(3-hydroxy-3-methylbutoxy)-5-(trifluoromethyl)benzamide

N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-2-(2-hydroxy-2-methylpropoxy)-5-(trifluoromethyl)benzamide

2-[(tert-butylamino)oxy]-N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-5-(trifluoromethyl)benzamide

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