5-(3,5-Bistrifluoromethylphenyl)-2-t-butyloxycarbonylamino-1-(3-indolyl)-4-penten-3-one

Base Information

Chemical Name:5-(3,5-Bistrifluoromethylphenyl)-2-t-butyloxycarbonylamino-1-(3-indolyl)-4-penten-3-one
CAS No.:156814-61-8
Molecular Formula:C₂₆H₂₄F₆N₂O₃
Molecular Weight:526.479
Hs Code.:

Synonyms:5-(3,5-Bistrifluoromethylphenyl)-2-t-butyloxycarbonylamino-1-(3-indolyl)-4-penten-3-one

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Chemical Property of 5-(3,5-Bistrifluoromethylphenyl)-2-t-butyloxycarbonylamino-1-(3-indolyl)-4-penten-3-one

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Technology Process of 5-(3,5-Bistrifluoromethylphenyl)-2-t-butyloxycarbonylamino-1-(3-indolyl)-4-penten-3-one

There total 6 articles about 5-(3,5-Bistrifluoromethylphenyl)-2-t-butyloxycarbonylamino-1-(3-indolyl)-4-penten-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 156814-60-7
2-t-Butyloxycarbonyl amino-1-(3-indolyl)-4-dimethylphosphono-3-butanone

: 401-95-6
3,5-Bis(trifluoromethyl)benzaldehyde

: 156814-61-8
5-(3,5-Bistrifluoromethylphenyl)-2-t-butyloxycarbonylamino-1-(3-indolyl)-4-penten-3-one

Guidance literature:: 2-t-Butyloxycarbonyl amino-1-(3-indolyl)-4-dimethylphosphono-3-butanone; With N-ethyl-N,N-diisopropylamine; lithium chloride; In acetonitrile; at 20 ℃; for 0.5h;

3,5-Bis(trifluoromethyl)benzaldehyde; In tetrahydrofuran; acetonitrile;

Reference yield:

: N-Methoxy-N-methyl 2-t-butyloxycarbonylamino-3-(3-indolyl)propionamide

: 156814-61-8
5-(3,5-Bistrifluoromethylphenyl)-2-t-butyloxycarbonylamino-1-(3-indolyl)-4-penten-3-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -70 - -55 °C / Inert atmosphere

1.2: 0.5 h

2.1: lithium chloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.5 h / 20 °C

With n-butyllithium; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; acetonitrile;

Reference yield:

: 5241-64-5,13139-14-5,112525-72-1
BOC-tryptophane

: 156814-61-8
5-(3,5-Bistrifluoromethylphenyl)-2-t-butyloxycarbonylamino-1-(3-indolyl)-4-penten-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 20 °C

2.1: n-butyllithium / tetrahydrofuran / 1 h / -70 - -55 °C / Inert atmosphere

2.2: 0.5 h

3.1: lithium chloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.5 h / 20 °C

With n-butyllithium; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium chloride; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;