Technology Process of [4S,3(6E)]-4-Benzyl-3-(5,5,8-trimethylnona-6,8-dienoyl)-2-oxazolidinone
There total 11 articles about [4S,3(6E)]-4-Benzyl-3-(5,5,8-trimethylnona-6,8-dienoyl)-2-oxazolidinone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(S)-4-Benzyl-2-oxazolidinone;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
Pivaloyl (E)-5,5,8-trimethylnona-6,8-dienoyl anhydride;
In
tetrahydrofuran; hexane;
at -78 - 4 ℃;
for 13h;
DOI:10.1055/s-2000-8220
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 83 percent / aq. KOH / methanol / 12 h / Heating
2.1: 9 g / Et3N / CH2Cl2 / 1 h / 20 °C
3.1: BuLi / tetrahydrofuran; hexane / 1 h / -78 °C
3.2: 78 percent / tetrahydrofuran; hexane / 13 h / -78 - 4 °C
With
potassium hydroxide; n-butyllithium; triethylamine;
In
tetrahydrofuran; methanol; hexane; dichloromethane;
1.1: Hydrolysis / 2.1: Acylation / 3.1: Metallation / 3.2: Acylation;
DOI:10.1055/s-2000-8220
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 9 g / Et3N / CH2Cl2 / 1 h / 20 °C
2.1: BuLi / tetrahydrofuran; hexane / 1 h / -78 °C
2.2: 78 percent / tetrahydrofuran; hexane / 13 h / -78 - 4 °C
With
n-butyllithium; triethylamine;
In
tetrahydrofuran; hexane; dichloromethane;
1.1: Acylation / 2.1: Metallation / 2.2: Acylation;
DOI:10.1055/s-2000-8220
