5-[2-(5-chloro-2-methoxybenzamido)ethyl]-2-(trifluoromethoxy)benzenesulfonamide

Base Information

Chemical Name:5-[2-(5-chloro-2-methoxybenzamido)ethyl]-2-(trifluoromethoxy)benzenesulfonamide
CAS No.:335456-28-5
Molecular Formula:C₁₇H₁₉ClN₂O₄S₂
Molecular Weight:414.934
Hs Code.:

Synonyms:5-[2-(5-chloro-2-methoxybenzamido)ethyl]-2-(trifluoromethoxy)benzenesulfonamide

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Chemical Property of 5-[2-(5-chloro-2-methoxybenzamido)ethyl]-2-(trifluoromethoxy)benzenesulfonamide

Chemical Property:

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Technology Process of 5-[2-(5-chloro-2-methoxybenzamido)ethyl]-2-(trifluoromethoxy)benzenesulfonamide

There total 6 articles about 5-[2-(5-chloro-2-methoxybenzamido)ethyl]-2-(trifluoromethoxy)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-[2-(5-chloro-2-methoxy-benzoylamino)-ethyl]-2-methylsulfanyl-benzenesulfonyl chloride

: 335456-28-5
5-[2-(5-chloro-2-methoxybenzamido)ethyl]-2-(trifluoromethoxy)benzenesulfonamide

Guidance literature:: With ammonium hydroxide; In acetone; at 20 ℃; for 1h;
DOI:10.1021/jm000985v

Reference yield:

: 138485-81-1
3-(4-(methylmercapto)phenyl)propionic acid

: 335456-28-5
5-[2-(5-chloro-2-methoxybenzamido)ethyl]-2-(trifluoromethoxy)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: TEA; azidodiphenylphosphate / 24 h / Heating

2: 2N aq. HCl / methanol / 2 h / Heating

3: pyridine / 1 h / 20 °C

4: ClSO₃H / 3 h / 20 °C

5: aq. NH₃ / acetone / 1 h / 20 °C

With pyridine; hydrogenchloride; chlorosulfonic acid; ammonium hydroxide; diphenyl phosphorazide; TEA; In methanol; acetone;
DOI:10.1021/jm000985v

Reference yield:

: 3446-89-7
4-(Methylthio)benzaldehyde

: 335456-28-5
5-[2-(5-chloro-2-methoxybenzamido)ethyl]-2-(trifluoromethoxy)benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: 63 percent / tetraethylammonium formiate / 95 - 100 °C

2: TEA; azidodiphenylphosphate / 24 h / Heating

3: 2N aq. HCl / methanol / 2 h / Heating

4: pyridine / 1 h / 20 °C

5: ClSO₃H / 3 h / 20 °C

6: aq. NH₃ / acetone / 1 h / 20 °C

With pyridine; hydrogenchloride; chlorosulfonic acid; ammonium hydroxide; diphenyl phosphorazide; TEA; Tetraethylammonium formate; In methanol; acetone;
DOI:10.1021/jm000985v