3-(4-bromophenyl)-2,5-diphenyl-[4-(triisopropylsilylethynyl)phenyl]cyclopenta-2,4-dien-1-one

Base Information

Chemical Name:3-(4-bromophenyl)-2,5-diphenyl-[4-(triisopropylsilylethynyl)phenyl]cyclopenta-2,4-dien-1-one
CAS No.:695152-68-2
Molecular Formula:C₄₀H₃₉BrOSi
Molecular Weight:643.739
Hs Code.:

Synonyms:3-(4-bromophenyl)-2,5-diphenyl-[4-(triisopropylsilylethynyl)phenyl]cyclopenta-2,4-dien-1-one

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Chemical Property of 3-(4-bromophenyl)-2,5-diphenyl-[4-(triisopropylsilylethynyl)phenyl]cyclopenta-2,4-dien-1-one

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Technology Process of 3-(4-bromophenyl)-2,5-diphenyl-[4-(triisopropylsilylethynyl)phenyl]cyclopenta-2,4-dien-1-one

There total 5 articles about 3-(4-bromophenyl)-2,5-diphenyl-[4-(triisopropylsilylethynyl)phenyl]cyclopenta-2,4-dien-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 102-04-5
1,3-Diphenylpropanone

: 695152-70-6
4,4'-bis(triisopropylsilylethynyl)benzil

: 695152-68-2
3-(4-bromophenyl)-2,5-diphenyl-[4-(triisopropylsilylethynyl)phenyl]cyclopenta-2,4-dien-1-one

Guidance literature:: With tetra(n-butyl)ammonium hydroxide; In methanol; tert-butyl alcohol; at 90 ℃; for 0.25h;
DOI:10.1002/chem.200305359

Reference yield:

: 16116-78-2
(4-bromophenyl)(trimethylsilyl)acetylene

: 695152-68-2
3-(4-bromophenyl)-2,5-diphenyl-[4-(triisopropylsilylethynyl)phenyl]cyclopenta-2,4-dien-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / PPh₃; CuI; Et₃N / [Pd(PPh₃)4] / toluene / 24 h / 20 °C

2: 84 percent / aq. NaOH / tetrahydrofuran; ethanol / 2 h / 80 °C

3: 81 percent / CuI; PPh₃; Et₃N / [PdCl₂(PPh₃)2] / toluene

4: 84 percent / iodine / dimethylsulfoxide / 12 h / 190 °C

5: 78 percent / tetrabutylammonium hydroxide / 2-methyl-propan-2-ol; methanol / 0.25 h / 90 °C

With sodium hydroxide; copper(l) iodide; tetra(n-butyl)ammonium hydroxide; iodine; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; toluene; tert-butyl alcohol; 1: Sonogashira coupling / 3: Sonogashira coupling / 5: Knoevenagel condensation;
DOI:10.1002/chem.200305359

Reference yield:

: 175345-90-1
1-((triisopropylsilyl)ethynyl)-4-ethynylbenzene

: 695152-68-2
3-(4-bromophenyl)-2,5-diphenyl-[4-(triisopropylsilylethynyl)phenyl]cyclopenta-2,4-dien-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / CuI; PPh₃; Et₃N / [PdCl₂(PPh₃)2] / toluene

2: 84 percent / iodine / dimethylsulfoxide / 12 h / 190 °C

3: 78 percent / tetrabutylammonium hydroxide / 2-methyl-propan-2-ol; methanol / 0.25 h / 90 °C

With copper(l) iodide; tetra(n-butyl)ammonium hydroxide; iodine; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; In methanol; dimethyl sulfoxide; toluene; tert-butyl alcohol; 1: Sonogashira coupling / 3: Knoevenagel condensation;
DOI:10.1002/chem.200305359