N-((R)-1-phenylethyl)-2-((R)-1-tosyl-2,3-dihydro-1H-benzo[g]indol-2-yl)acetamide

Base Information

Chemical Name:N-((R)-1-phenylethyl)-2-((R)-1-tosyl-2,3-dihydro-1H-benzo[g]indol-2-yl)acetamide
CAS No.:1309578-89-9
Molecular Formula:C₂₉H₂₈N₂O₃S
Molecular Weight:484.619
Hs Code.:

Synonyms:N-((R)-1-phenylethyl)-2-((R)-1-tosyl-2,3-dihydro-1H-benzo[g]indol-2-yl)acetamide

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Chemical Property of N-((R)-1-phenylethyl)-2-((R)-1-tosyl-2,3-dihydro-1H-benzo[g]indol-2-yl)acetamide

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Technology Process of N-((R)-1-phenylethyl)-2-((R)-1-tosyl-2,3-dihydro-1H-benzo[g]indol-2-yl)acetamide

There total 3 articles about N-((R)-1-phenylethyl)-2-((R)-1-tosyl-2,3-dihydro-1H-benzo[g]indol-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 2-(1-tosyl-2,3-dihydro-1H-benzo[g]indol-2-yl)acetic acid

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 1309578-89-9
N-((R)-1-phenylethyl)-2-((R)-1-tosyl-2,3-dihydro-1H-benzo[g]indol-2-yl)acetamide

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃;
DOI:10.1039/c1cc10999e

Reference yield:

: 56799-90-7
N-(2-allylnaphthalen-1-yl)-4-methylbenzenesulfonamide

: 1309578-89-9
N-((R)-1-phenylethyl)-2-((R)-1-tosyl-2,3-dihydro-1H-benzo[g]indol-2-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 55 °C

2: (η6-Me6C6)Ru(TsN(CH(2,4,6-C6H2Me3))2NH) / toluene / 24 h / -15 °C

3: water; potassium hydroxide / methanol / 1 h / 50 °C

4: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C

With Hoveyda-Grubbs catalyst second generation; (η6-Me6C6)Ru(TsN(CH(2,4,6-C6H2Me3))2NH); water; benzotriazol-1-ol; dicyclohexyl-carbodiimide; potassium hydroxide; In methanol; dichloromethane; toluene; 2: Michael condensation;
DOI:10.1039/c1cc10999e

Reference yield:

: 1309578-54-8
(E)-methyl 4-(1-(4-methylphenylsulfonamido)naphthalen-2-yl)but-2-enoate

: 1309578-89-9
N-((R)-1-phenylethyl)-2-((R)-1-tosyl-2,3-dihydro-1H-benzo[g]indol-2-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: (η6-Me6C6)Ru(TsN(CH(2,4,6-C6H2Me3))2NH) / toluene / 24 h / -15 °C

2: water; potassium hydroxide / methanol / 1 h / 50 °C

3: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C

With (η6-Me6C6)Ru(TsN(CH(2,4,6-C6H2Me3))2NH); water; benzotriazol-1-ol; dicyclohexyl-carbodiimide; potassium hydroxide; In methanol; dichloromethane; toluene; 1: Michael condensation;
DOI:10.1039/c1cc10999e