5-bromo-N-(4-fluorophenyl)-N-((2-(trimethylsilyl)ethoxy)methyl)pyrimidine-2-carboxamide

Base Information

Chemical Name:5-bromo-N-(4-fluorophenyl)-N-((2-(trimethylsilyl)ethoxy)methyl)pyrimidine-2-carboxamide
CAS No.:1419603-21-6
Molecular Formula:C₁₇H₂₁BrFN₃O₂Si
Molecular Weight:426.361
Hs Code.:

Synonyms:5-bromo-N-(4-fluorophenyl)-N-((2-(trimethylsilyl)ethoxy)methyl)pyrimidine-2-carboxamide

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Chemical Property of 5-bromo-N-(4-fluorophenyl)-N-((2-(trimethylsilyl)ethoxy)methyl)pyrimidine-2-carboxamide

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Technology Process of 5-bromo-N-(4-fluorophenyl)-N-((2-(trimethylsilyl)ethoxy)methyl)pyrimidine-2-carboxamide

There total 4 articles about 5-bromo-N-(4-fluorophenyl)-N-((2-(trimethylsilyl)ethoxy)methyl)pyrimidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1419603-19-2
5-bromo-N-(4-fluorophenyl)pyrimidine-2-carboxamide

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1419603-21-6
5-bromo-N-(4-fluorophenyl)-N-((2-(trimethylsilyl)ethoxy)methyl)pyrimidine-2-carboxamide

Guidance literature:: 5-bromo-N-(4-fluorophenyl)pyrimidine-2-carboxamide; With sodium hydride; In N,N-dimethyl-formamide; at -5 ℃; for 0.5h; Inert atmosphere;

(2-trimethylethylsilylethoxy)methyl chloride; In N,N-dimethyl-formamide; at -5 - 20 ℃; for 2h;

Reference yield:

: 37131-87-6
5-bromo-2-pyrimidinecarboxylic acid

: 1419603-21-6
5-bromo-N-(4-fluorophenyl)-N-((2-(trimethylsilyl)ethoxy)methyl)pyrimidine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / benzene / 2 h / 100 °C

2.1: dichloromethane / 16 h / 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -5 °C / Inert atmosphere

3.2: 2 h / -5 - 20 °C

With thionyl chloride; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; benzene;

Reference yield:

: 1013335-78-8
5-bromopyridine-2-carboxylic acid chloride

: 1419603-21-6
5-bromo-N-(4-fluorophenyl)-N-((2-(trimethylsilyl)ethoxy)methyl)pyrimidine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 16 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -5 °C / Inert atmosphere

2.2: 2 h / -5 - 20 °C

With sodium hydride; In dichloromethane; N,N-dimethyl-formamide;