5-bromo-N-(4-(7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)butyl)-2,3-dimethoxybenzamide

Base Information

Chemical Name:5-bromo-N-(4-(7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)butyl)-2,3-dimethoxybenzamide
CAS No.:1285548-95-9
Molecular Formula:C₂₅H₃₃BrN₂O₅
Molecular Weight:521.451
Hs Code.:

Synonyms:5-bromo-N-(4-(7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)butyl)-2,3-dimethoxybenzamide

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Chemical Property of 5-bromo-N-(4-(7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)butyl)-2,3-dimethoxybenzamide

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Technology Process of 5-bromo-N-(4-(7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)butyl)-2,3-dimethoxybenzamide

There total 5 articles about 5-bromo-N-(4-(7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)butyl)-2,3-dimethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1285549-08-7
4-(7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)butan-1-amine

: 107188-91-0
5-bromo-2,3-dimethoxybenzoic acid chloride

: 1285548-95-9
5-bromo-N-(4-(7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)butyl)-2,3-dimethoxybenzamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2011.02.006

Reference yield:

: 86499-67-4
7,8-dimethoxy-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one

: 1285548-95-9
5-bromo-N-(4-(7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)butyl)-2,3-dimethoxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: borane-THF / tetrahydrofuran / 0 - 20 °C

2: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 2 h / 60 °C

3: hydrazine hydrate / methanol / 3 h / Reflux

4: triethylamine / dichloromethane / 20 °C

With borane-THF; potassium carbonate; hydrazine hydrate; triethylamine; sodium iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.02.006

Reference yield:

: 847173-30-2
7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine

: 1285548-95-9
5-bromo-N-(4-(7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)butyl)-2,3-dimethoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 2 h / 60 °C

2: hydrazine hydrate / methanol / 3 h / Reflux

3: triethylamine / dichloromethane / 20 °C

With potassium carbonate; hydrazine hydrate; triethylamine; sodium iodide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.02.006