1-{[(8beta)-6-methylergolin-8-yl]methyl}imidazolidine-2,4-dione

Base Information

• Chemical Name: 1-{[(8beta)-6-methylergolin-8-yl]methyl}imidazolidine-2,4-dione
• CAS No.: 95688-34-9
• Molecular Formula: C19H22N4O2
• Molecular Weight: 338.4036
• Mol file: 95688-34-9.mol

Synonyms:1-((6aR,9R,10aR)-7-Methyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinolin-9-ylmethyl)-imidazolidine-2,4-dione;1-[(6-methylergolin -8β- yl)methyl]-2,4-imidazolidinedione;6-Methyl-8β-(2,4-dioxo-1-imidazolidinyl-methyl)-ergoline;

Chemical Property of 1-{[(8beta)-6-methylergolin-8-yl]methyl}imidazolidine-2,4-dione

Chemical Property:

• PSA: 68.44000
• Density: 1.319g/cm³
• LogP: 1.88430

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{[(8beta)-6-methylergolin-8-yl]methyl}imidazolidine-2,4-dione

There total 7 articles about 1-{[(8beta)-6-methylergolin-8-yl]methyl}imidazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

potassium cyanate (590-28-3) + 6-methyl-8β-(N-ethoxycarbonylmethyl-aminomethyl)-ergoline (95688-31-6) → FCE 22716 (95688-34-9)

Guidance literature:

With hydrogenchloride; In water; 1.) r.t., 2 h, 2.) 75 deg C, 5 h; overnight;

DOI:10.1016/S0014-827X(98)00023-8

Reference yield:

Dihydrolysergamine (1940-12-1) → FCE 22716 (95688-34-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / K₂CO₃ / dimethylformamide / 5 h / Ambient temperature

2: 94 percent / HCl / H₂O / 1.) r.t., 2 h, 2.) 75 deg C, 5 h; overnight

With hydrogenchloride; potassium carbonate; In water; N,N-dimethyl-formamide;

DOI:10.1016/S0014-827X(98)00023-8

Reference yield:

2-((6aR,9R,10aR)-7-Methyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinolin-9-ylmethyl)-isoindole-1,3-dione (160730-51-8) → FCE 22716 (95688-34-9)

Guidance literature:

Multi-step reaction with 3 steps

1: N₂H₄ / methanol / Ambient temperature

2: TEA / dimethylformamide / Ambient temperature

3: H₂O / 50 °C

With TEA; hydrazine; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(98)00166-8

upstream raw materials:

cyanic acid

6-methyl-8β-(N-ethoxycarbonylmethyl-aminomethyl)-ergoline

potassium cyanate

Dihydrolysergamine