(2S)-N-<(2S)-2-Methyl-1-oxobutyl>phenylalanin-(1S)-<(2R,3R)-3-acetoxy-1-<(2S)-2-benzyloxycarbonylamino-3-methyl-1-oxobutyl>-2-pyrrolidinyl>-2-(benzyloxycarbonyl)-ethylester

Base Information

Chemical Name:(2S)-N-<(2S)-2-Methyl-1-oxobutyl>phenylalanin-(1S)-<(2R,3R)-3-acetoxy-1-<(2S)-2-benzyloxycarbonylamino-3-methyl-1-oxobutyl>-2-pyrrolidinyl>-2-(benzyloxycarbonyl)-ethylester
CAS No.:107692-80-8
Molecular Formula:C₄₃H₅₃N₃O₁₀
Molecular Weight:771.908
Hs Code.:

(2S)-N-<(2S)-2-Methyl-1-oxobutyl>phenylalanin-(1S)-<(2R,3R)-3-acetoxy-1-<(2S)-2-benzyloxycarbonylamino-3-methyl-1-oxobutyl>-2-pyrrolidinyl>-2-(benzyloxycarbonyl)-ethylester

Synonyms:(2S)-N-<(2S)-2-Methyl-1-oxobutyl>phenylalanin-(1S)-<(2R,3R)-3-acetoxy-1-<(2S)-2-benzyloxycarbonylamino-3-methyl-1-oxobutyl>-2-pyrrolidinyl>-2-(benzyloxycarbonyl)-ethylester

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Chemical Property of (2S)-N-<(2S)-2-Methyl-1-oxobutyl>phenylalanin-(1S)-<(2R,3R)-3-acetoxy-1-<(2S)-2-benzyloxycarbonylamino-3-methyl-1-oxobutyl>-2-pyrrolidinyl>-2-(benzyloxycarbonyl)-ethylester

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Technology Process of (2S)-N-<(2S)-2-Methyl-1-oxobutyl>phenylalanin-(1S)-<(2R,3R)-3-acetoxy-1-<(2S)-2-benzyloxycarbonylamino-3-methyl-1-oxobutyl>-2-pyrrolidinyl>-2-(benzyloxycarbonyl)-ethylester

There total 8 articles about (2S)-N-<(2S)-2-Methyl-1-oxobutyl>phenylalanin-(1S)-<(2R,3R)-3-acetoxy-1-<(2S)-2-benzyloxycarbonylamino-3-methyl-1-oxobutyl>-2-pyrrolidinyl>-2-(benzyloxycarbonyl)-ethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10084-80-7
N^α-benzyloxycarbonyl-L-valine anhydride

: 107692-80-8
(2S)-N-<(2S)-2-Methyl-1-oxobutyl>phenylalanin-(1S)-<(2R,3R)-3-acetoxy-1-<(2S)-2-benzyloxycarbonylamino-3-methyl-1-oxobutyl>-2-pyrrolidinyl>-2-(benzyloxycarbonyl)-ethylester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) trifluoroacetic acid 2.) N-methylmorpholine / 2.) acetonitrile, -5 deg C, 12 h

2: 94 percent / toluene-4-sulphonic acid monohydrate / CH₂Cl₂ / 3 h / 20 °C

4: 87 percent / 4-(dimethylamino)pyridine / 1.) 2 h, -20 deg C, 2.) 12 h, 5 deg C

5: 1.) trifluoroacetic acid, 2.) N-methylmorpholine / 1.) 20 min, 0 deg C to room temp. 2.) methylene dichloride, 0 - 5 degC

With 4-methyl-morpholine; dmap; toluene-4-sulfonic acid; trifluoroacetic acid; In dichloromethane;
DOI:10.1002/jlac.198619860111

Reference yield:

: 87125-57-3,87172-71-2,131434-96-3
rac-(3aR^*,7S^*,7aR^*)-1-tert-Butyloxycarbonyl-1,2,3,3a,5,6,7,7a-octahydro-7-hydroxypyrano<3,2-b>pyrrol-5-on

: 107692-80-8
(2S)-N-<(2S)-2-Methyl-1-oxobutyl>phenylalanin-(1S)-<(2R,3R)-3-acetoxy-1-<(2S)-2-benzyloxycarbonylamino-3-methyl-1-oxobutyl>-2-pyrrolidinyl>-2-(benzyloxycarbonyl)-ethylester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) trifluoroacetic acid 2.) N-methylmorpholine / 2.) acetonitrile, -5 deg C, 12 h

2: 94 percent / toluene-4-sulphonic acid monohydrate / CH₂Cl₂ / 3 h / 20 °C

4: 87 percent / 4-(dimethylamino)pyridine / 1.) 2 h, -20 deg C, 2.) 12 h, 5 deg C

5: 1.) trifluoroacetic acid, 2.) N-methylmorpholine / 1.) 20 min, 0 deg C to room temp. 2.) methylene dichloride, 0 - 5 degC

With 4-methyl-morpholine; dmap; toluene-4-sulfonic acid; trifluoroacetic acid; In dichloromethane;
DOI:10.1002/jlac.198619860111

Reference yield:

: 107692-75-1
(3aR,7S,7aR)-1-<(2S)-2-Benzyloxycarbonylamino-3-methyl-1-oxobutyl>-1,2,3,3a,5,6,7,7a-octahydro-7-hydroxypyrano<3,2-b>pyrrol-5-on

: 107692-80-8
(2S)-N-<(2S)-2-Methyl-1-oxobutyl>phenylalanin-(1S)-<(2R,3R)-3-acetoxy-1-<(2S)-2-benzyloxycarbonylamino-3-methyl-1-oxobutyl>-2-pyrrolidinyl>-2-(benzyloxycarbonyl)-ethylester

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / toluene-4-sulphonic acid monohydrate / CH₂Cl₂ / 3 h / 20 °C

3: 87 percent / 4-(dimethylamino)pyridine / 1.) 2 h, -20 deg C, 2.) 12 h, 5 deg C

4: 1.) trifluoroacetic acid, 2.) N-methylmorpholine / 1.) 20 min, 0 deg C to room temp. 2.) methylene dichloride, 0 - 5 degC

With 4-methyl-morpholine; dmap; toluene-4-sulfonic acid; trifluoroacetic acid; In dichloromethane;
DOI:10.1002/jlac.198619860111