ethyl 12-bromo-3-(2,4-dichlorophenyl)-3,4-diazatricyclo[8.4.0.0^2,6]tetradeca-1⁽¹⁴⁾,2⁽⁶⁾,4,10,12-pentaene-5-carboxylate

Base Information

• Chemical Name: ethyl 12-bromo-3-(2,4-dichlorophenyl)-3,4-diazatricyclo[8.4.0.0^2,6]tetradeca-1⁽¹⁴⁾,2⁽⁶⁾,4,10,12-pentaene-5-carboxylate
• CAS No.: 870679-50-8
• Molecular Formula: C₂₁H₁₇BrCl₂N₂O₂
• Molecular Weight: 480.188

Synonyms:ethyl 12-bromo-3-(2,4-dichlorophenyl)-3,4-diazatricyclo[8.4.0.0^2,6]tetradeca-1⁽¹⁴⁾,2⁽⁶⁾,4,10,12-pentaene-5-carboxylate

Chemical Property of ethyl 12-bromo-3-(2,4-dichlorophenyl)-3,4-diazatricyclo[8.4.0.0^2,6]tetradeca-1⁽¹⁴⁾,2⁽⁶⁾,4,10,12-pentaene-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 12-bromo-3-(2,4-dichlorophenyl)-3,4-diazatricyclo[8.4.0.0^2,6]tetradeca-1⁽¹⁴⁾,2⁽⁶⁾,4,10,12-pentaene-5-carboxylate

There total 5 articles about ethyl 12-bromo-3-(2,4-dichlorophenyl)-3,4-diazatricyclo[8.4.0.0^2,6]tetradeca-1⁽¹⁴⁾,2⁽⁶⁾,4,10,12-pentaene-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

ethyl γ-(7-bromo-1-oxo-2,3,4,5-tetrahydrobenzocyclohepten-2-yl)-α-oxoacetate (870679-54-2) + 2,4-dichlorophenyl hydrazine hydrochloride (5446-18-4) → ethyl 12-bromo-3-(2,4-dichlorophenyl)-3,4-diazatricyclo[8.4.0.02,6]tetradeca-1(14),2(6),4,10,12-pentaene-5-carboxylate (870679-50-8)

Guidance literature:

In ethanol; for 3h; Heating;

DOI:10.1021/jm050317f

Reference yield:

5-(3-bromophenyl)pent-4-enoic acid (870679-57-5) → ethyl 12-bromo-3-(2,4-dichlorophenyl)-3,4-diazatricyclo[8.4.0.02,6]tetradeca-1(14),2(6),4,10,12-pentaene-5-carboxylate (870679-50-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / H₂ / PtO₂ / ethanol / 2 h / 20 °C

2: 64 percent / polyphosphoric acid / 1 h / 130 °C

3: 90 percent / NaOEt / ethanol / 9 h / 20 °C

4: 78 percent / ethanol / 3 h / Heating

With PPA; hydrogen; sodium ethanolate; platinum(IV) oxide; In ethanol;

DOI:10.1021/jm050317f

Reference yield:

(3-carboxypropyl)(triphenyl)phosphonium bromide (17857-14-6) → ethyl 12-bromo-3-(2,4-dichlorophenyl)-3,4-diazatricyclo[8.4.0.02,6]tetradeca-1(14),2(6),4,10,12-pentaene-5-carboxylate (870679-50-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: t-BuOK / dimethylsulfoxide / 0.33 h / 20 °C

1.2: 78 percent / dimethylsulfoxide / 4 h / 20 °C

2.1: 95 percent / H₂ / PtO₂ / ethanol / 2 h / 20 °C

3.1: 64 percent / polyphosphoric acid / 1 h / 130 °C

4.1: 90 percent / NaOEt / ethanol / 9 h / 20 °C

5.1: 78 percent / ethanol / 3 h / Heating

With PPA; potassium tert-butylate; hydrogen; sodium ethanolate; platinum(IV) oxide; In ethanol; dimethyl sulfoxide;

DOI:10.1021/jm050317f

upstream raw materials:

ethyl γ-(7-bromo-1-oxo-2,3,4,5-tetrahydrobenzocyclohepten-2-yl)-α-oxoacetate

2,4-dichlorophenyl hydrazine hydrochloride

5-(3-bromophenyl)pent-4-enoic acid

5-(3'-bromophenyl)pentanoic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 870679-50-8 ethyl 12-bromo-3-(2,4-dichlorophenyl)-3,4-diazatricyclo[8.4.0.0^2,6]tetradeca-1⁽¹⁴⁾,2⁽⁶⁾,4,10,12-pentaene-5-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send