3-(N-(benzyloxycarbonyl)amino)-3-((2-methyl-ethoxypropionyl)hydroxyphosphinyl) butanoic acid

Base Information

Chemical Name:3-(N-(benzyloxycarbonyl)amino)-3-((2-methyl-ethoxypropionyl)hydroxyphosphinyl) butanoic acid
CAS No.:260390-97-4
Molecular Formula:C₁₈H₂₆NO₈P
Molecular Weight:415.38
Hs Code.:

Synonyms:3-(N-(benzyloxycarbonyl)amino)-3-((2-methyl-ethoxypropionyl)hydroxyphosphinyl) butanoic acid

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Chemical Property of 3-(N-(benzyloxycarbonyl)amino)-3-((2-methyl-ethoxypropionyl)hydroxyphosphinyl) butanoic acid

Chemical Property:

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Technology Process of 3-(N-(benzyloxycarbonyl)amino)-3-((2-methyl-ethoxypropionyl)hydroxyphosphinyl) butanoic acid

There total 4 articles about 3-(N-(benzyloxycarbonyl)amino)-3-((2-methyl-ethoxypropionyl)hydroxyphosphinyl) butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 260390-96-3
4-amino-4-[(2-ethoxycarbonyl-propyl)-hydroxy-phosphinoyl]-butyric acid

: 260390-97-4
3-(N-(benzyloxycarbonyl)amino)-3-((2-methyl-ethoxypropionyl)hydroxyphosphinyl) butanoic acid

Guidance literature:: With magnesium oxide; In water; for 1h;
DOI:10.1016/S0040-4020(99)00910-2

Reference yield:

: 260390-89-4
2-methyl-3((1-(N-(tert-butyloxycarbonyl)amino)-3-phenylpropyl)-hydroxyphosphinyl) propanoic acid, ethyl ester

: 260390-97-4
3-(N-(benzyloxycarbonyl)amino)-3-((2-methyl-ethoxypropionyl)hydroxyphosphinyl) butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / silver oxide / CHCl₃ / 3 h / Heating

2: 47 percent / sodium metaperiodate / ruthenium trichloride / ethyl acetate; H₂O / 3 h

3: 94 percent / aq. TFA / CH₂Cl₂ / 3 h / 20 °C

4: 79 percent / MgO / H₂O / 1 h

With sodium periodate; magnesium oxide; trifluoroacetic acid; silver(l) oxide; ruthenium trichloride; In dichloromethane; chloroform; water; ethyl acetate; 1: Esterification / 2: Oxidation / 3: Hydrolysis / 4: Acylation;
DOI:10.1016/S0040-4020(99)00910-2

Reference yield:

: 2-methyl-3((1-(N-(tert-butyloxycarbonyl)amino)-3-phenylpropyl)-adamantyloxyphosphinyl) propanoic acid, ethyl ester

: 260390-97-4
3-(N-(benzyloxycarbonyl)amino)-3-((2-methyl-ethoxypropionyl)hydroxyphosphinyl) butanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 47 percent / sodium metaperiodate / ruthenium trichloride / ethyl acetate; H₂O / 3 h

2: 94 percent / aq. TFA / CH₂Cl₂ / 3 h / 20 °C

3: 79 percent / MgO / H₂O / 1 h

With sodium periodate; magnesium oxide; trifluoroacetic acid; ruthenium trichloride; In dichloromethane; water; ethyl acetate; 1: Oxidation / 2: Hydrolysis / 3: Acylation;
DOI:10.1016/S0040-4020(99)00910-2